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Test Code:
UREAU24

Order Name:
Urea-N (U-24 hrs)

 
Useful For:
Assessment of renal failure (prerenal vs acute kidney injury)
 
Methodology:
Urease
 
AliasesName:
Urea N Urine 24 hrs
 
 
 
Test Code:
UREAU24

Order Name:
Urea-N (U-24 hrs)

 
Collection Specimen Or Container:
24-hour urine, Clean containner with preservative
Preservative -  can be selected as list below:
  1. 20 mL of 6N HCL (Preferred) or
  2. 10 mL of 25% HCl or
  3. non preservative if order with Protein (U-24 hrs) or Microalbumin ( U-24 hrs)
Note:
  • Please keep in refrigerated (2-8°C) during collection and transportation
  • 24-hours volume is required.
 
Specimen Testing Type:
24-hour urine,minimum volume 10 mL
 
Sub Mission Container:
Clean container
 
Rejection Criteria:
Wrong preservative type will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
24 hours urine Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 1 month
 
 
 
Test Code:
UREAU24

Order Name:
Urea-N (U-24 hrs)

 
Method detail:
Urease
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
UREAU24

Order Name:
Urea-N (U-24 hrs)

 
 
Clinical Information:
Urea is a low molecular weight substance (Mol Wt=60) that is freely filtered by glomeruli and the majority is excreted into the urine, although variable amounts are reabsorbed along the nephron. It is the major end product of protein metabolism in humans and other mammals. Approximately 50% of urinary solute excretion and 90% to 95% of total nitrogen excretion is composed of urea under normal conditions. Factors that tend to increase urea excretion include increases in glomerular filtration rate, increased dietary protein intake, protein catabolic conditions, and water diuretic states. Factors that reduce urea excretion include low protein intake and conditions which result in low urine output (eg, dehydration). Urea excretion is a useful marker of protein metabolism.

In oliguric patients with a rising creatinine a fractional excretion of urea <35% is consistent with a prerenal cause, while values >35% are more consistent with acute kidney injury.(2) The fractional excretion of sodium is also used for this purpose, but may be more affected by diuretics. Therefore, the fractional excretion of urea may be particularly useful for patients receiving diuretics.
 
Reference Value:
12 – 20 g/day
 
Interpretation:
Because multiple factors (glomerular filtration rate, dietary protein intake, protein catabolic rate, hydration state, etc.) can independently affect the urinary excretion of urea, all of these factors must be taken into account when interpreting the results.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect ® Urea Nitrogen, Abbott Laboratories Diagnostics Division, Aboott Park, IL 600064, USA. November 2015
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)