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Clear
 
Test Code:
090-80-2020-01

Order Name:
Total Arsenic (Urine)

 
Useful For:
Screening test for detection of occupational exposure to arsenic in random urine specimens
 
Methodology:
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
 
AliasesName:
AS (Arsenic), Urine
 
 
 
Test Code:
090-80-2020-01

Order Name:
Total Arsenic (Urine)

 
Collection Specimen Or Container:
Urine, Clean container 
 
Specimen Testing Type:
Urine, minimum volume 10 mL
 
Sub Mission Container:
Clean container
 
Specimen Stabillity:
Specimen Type Temperature Time
Urine Refrigerated, 2oC to 8oC 14 days

 
 
 
 
Test Code:
090-80-2020-01

Order Name:
Total Arsenic (Urine)

 
Method detail:
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
 
Schedule:
Tested on Tuesday and Friday at 7.00 a.m.
 
Turnaround Time:
Result reporting within Wednesday or Saturday, before 3.00 p.m.
 
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
1 month
 
 
 
Test Code:
090-80-2020-01

Order Name:
Total Arsenic (Urine)

 
 
Clinical Information:
The most common oxidation numbers of arsenic are +5, +3, and −3, in which the element is able to form both inorganic and organic compounds in the environment and within the human body (Hei and Filipic, 2004). In combination with other elements such as oxygen, sulphur and chlorine the element is referred to as inorganic
arsenic and as combined with hydrogen and carbon as organic arsenic. Since most arsenic compounds are colourless and/or do not smell, the presence of arsenic in food, water or air, is a serious human health risk.             Arsenic is toxic to the majority of organ systems; inorganic arsenic being more toxic than methylated organic arsenic (Mandal and Suzuki, 2002). The trivalent forms are the most toxic and react with thiol groups of proteins. 
 
Reference Value:
< 30 µg/g creatinine
 
Interpretation:
Arsenic toxicity involve genetic changes, the involvement of increased oxidative stress, enhanced cell proliferation and altered gene expression. Arsenic is known to induce hypoxia signalling pathways. Arsenic is a well-documented carcinogen in a number of studies (Waalkes et al., 2004). Chronic exposure to inorganic arsenic from contaminated water is responsible for various adverse health effects such as developing tumours of the lung, skin, liver, bladder and kidney. Skin lesions, peripheral neuropathy and anemia are hallmarks of chronic arsenic exposure. Arsenic is also a potential risk factor for atherosclerosis.
 
Clinical Reference:
  1. แสงโฉม เกิดคล้าย, บรรณาธิการ. แนวทางการวินิจฉัยเพื่อการรายงานโรคจากการประกอบอาชีพและ สิ่งแวดล้อม. พิมพ์ครั้งที่1. สำนักระบาดวิทยา กรมควบคุมโรค กระทรวงสาธารณสุข. สิงหาคม 2547:หน้า 22-33
  2. NCCLS document C38-A, Control of Pre analytical Variation in trace Element Determinations; Approved Guideline, 1997
  3. Biomarker Testing of Industrial Chemicals; Version 2018
  4. www.Thaitox.com
  5. The handbook of Environmental Chemistry Volume 3 Part A, Handbook on the toxicology of metals. Volume I., Ärztlicher Befundbericht, IMD Institut für Medizinische Diagnostik Berlin-Potsdam GbR, Nicolaistraße 22 - 12247 Berlin (Steglitz).
  6. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)
  7. K. Jomova, M. Valko, Advances in metal-induced oxidative stress and human disease, Toxicology 283 (2011) 65–87