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Test Code:
090-30-2730

Order Name:
TSH Receptor Antibody

 
Useful For:
  • Determination of autoantibodies to TSH receptor in human serum. 
  • Used as an aid in the differential diagnosis of Graves' disease.
 
Methodology:
Electrochemiluminescence method (ECLIA)
 
AliasesName:
Antibodies to TSH receptor
TRAb (Thyrotropin Receptor Antibody)
Graves' Disease
Anti TSH receptor
 
 
 
Test Code:
090-30-2730

Order Name:
TSH Receptor Antibody

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis 4+
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 3 days
Frozen, -15oC to -25oC 1 month
 
 
 
Test Code:
090-30-2730

Order Name:
TSH Receptor Antibody

 
Method detail:
Electrochemiluminescence method (ECLIA)
 
Schedule:
Test daily (08:00 a.m. - 15:00 p.m.)
 
Turnaround Time:
Specimen collected to reported within 3:00 Hours (180 Mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-2730

Order Name:
TSH Receptor Antibody

 
 
Clinical Information:
Hyperthyroidism in Graves' disease (autoimmune hyperthyroidism) is typically caused by autoantibodies to the thyroid stimulating hormone receptor (TSHR), and measurement of these TSHR antibodies (TRAb) can
be useful in disease diagnosis and management.

TSH autoantibodies can be classified as stimulating, blocking or neutral depending on their mechanism of action. Despite having actions similar to TSH, TSHR stimulating antibodies are not subject to the negative feedback mechanisms associated with TSH, leading to prolonged activation of the TSHR. This results in the elevated thyroid hormone levels and clinical thyrotoxic state associated with Graves’ disease.
 
Reference Value:
0 – 1.75 IU/L
 
Clinical Reference:
Manufacturer’s reagent package insert, Elecsys Anti-TSHR, 2019-01,V.14, Roche Diagnostics GmbH, D68305 Mannheim.