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Test Code:
092-10-0022

Order Name:
SLCO1B1 genotyping (3 SNPs - Fast track)

 
Useful For:
Identifying patients who may be at risk for altered metabolism of drugs that are modified by SLCO1B1. Predicting drug response to Simvastatin and Statin group.
 
Methodology:
Real-time PCR
 
AliasesName:
SLCO1B1
pgx
Pharmacogenetics
Pharmacogenomics
 
 
 
Test Code:
092-10-0022

Order Name:
SLCO1B1 genotyping (3 SNPs - Fast track)

 
Collection Specimen Or Container:
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube, minimum volume 1.5 ml
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Use heparin as anticoagulant, Severe clotted specimen will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
EDTA Whole Blood Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
092-10-0022

Order Name:
SLCO1B1 genotyping (3 SNPs - Fast track)

 
Method detail:
Real-time PCR
 
Schedule:
Test Daily
 
Turnaround Time:
Received specimen to report within 3 days
 
Performing Location:
Research and Development, Tel. 14252
 
Specimen Retention Time:
3 months
 
 
 
Test Code:
092-10-0022

Order Name:
SLCO1B1 genotyping (3 SNPs - Fast track)

 
 
Clinical Information:
SLCO1B1 is an influx transporter that moves drugs into cells. Variations in SLCO1B1 may affect the blood levels of drugs that are substrates for this transporter. Statins are one of the most common classes of medications affected by this transporter. Variations that result in decreased transporter activity may result in increased statin blood levels and increase the risk of adverse effects, such as myalgia and rhabdomyolysis. SLCO1B1-based dosing guidelines are available for statins. Providers should consider genotyping patients who are initiating statin therapy or those who have experienced adverse effects to statins in the past. Genetic variants tested for SLCO1B1 are *1a, *1b,*5, *15,*17.
 
Clinical Reference:
Ramsey LB, et al. The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for SLCO1B1 and Simvastatin-induced Myopathy: 2014 Update. Clin Pharmacol Ther. 2014 Oct;96(4):423-8. doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11.