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Test Code (รหัสการทดสอบ):
NTBNP

Order Name (ชื่อการทดสอบ):
Pro-BNP (NT pro B-Natriuretic peptide)

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Lithium heparin (Green top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 50 Mins.
 
Useful For (ประโยชน์การทดสอบ):
  • Determination of N‑terminal pro B‑type natriuretic peptide in human plasma.
  • Indicated as an aid in the diagnosis of individuals suspected of having congestive heart failure and detection of mild forms of cardiac dysfunction.
  • Aids in the assessment of heart failure severity in patients diagnosed with congestive heart failure.
  • Indicated for the risk stratification of patients with acute coronary syndrome and congestive heart failure.

Used for monitoring the treatment in patients with left ventricular dysfunction.
 
Methodology (วิธีการทดสอบ):
Electrochemiluminescence method (ECLIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
NT Pro BNP
NT pro B-Natriuretic peptide
N Terminal proBNP
ProBNP (B-Type Natriuretic Peptide)
 
 
 
Test Code (รหัสการทดสอบ):
NTBNP

Order Name (ชื่อการทดสอบ):
Pro-BNP (NT pro B-Natriuretic peptide)

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Lithium heparin (Green top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Lithium heparin Plasma, minimum volume 1 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: 4+ reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Lithium heparin plasma Room temperature, 20oC to 25oC 3 days
Refrigerated, 2oC to 8oC 6 days
Frozen, -20oC 24 months
 
 
 
Test Code (รหัสการทดสอบ):
NTBNP

Order Name (ชื่อการทดสอบ):
Pro-BNP (NT pro B-Natriuretic peptide)

 
Method detail (วิธีการทดสอบ):
Electrochemiluminescence method (ECLIA)
 
Schedule (ตารางการทดสอบ):
Tested Daily (24 Hours)
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 50 Mins.
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
NTBNP

Order Name (ชื่อการทดสอบ):
Pro-BNP (NT pro B-Natriuretic peptide)

 
 
Clinical Information (ข้อมูลทางคลินิก):
The test is also useful in the early stages of heart failure, where symptoms may be transient rather than present all the time. The high sensitivity of NT‑proBNP allows also the detection of mild forms of cardiac dysfunction in asymptomatic patients with structural heart disease. NT‑proBNP can also be used for prognostic applications in patients with acute coronary syndrome. The GUSTO IV study, with more than 6800 patients, showed that NT‑proBNP was the strongest independent predictor of one year mortality in patients with acute coronary syndrome. In chronic heart failure, serial measurement of NT‑proBNP concentration can be used to monitor the disease progression, to predict outcomes and evaluate the success of treatment. Elevated NT‑proBNP values are strongly predictive of adverse outcomes and rising values identify a risk, while significant lowering of NT‑proBNP denotes improved outcomes and better prognosis. In addition NT‑proBNP can be used to identify patients at higher risk of cardiotoxicity which can lead to heart failure and may be helpful in
monitoring the use and dosing of cardiotoxic tumor drugs or interventions causing fluid retention or volume overload (e.g. COX‑2 inhibitors, nonsteroidal anti‑inflammatory drugs).
 
Reference Value (ค่าอ้างอิง):
Diagnosis
Rule-in acute heart failure (HFSA)
Heart failure can be ruled-in in the emergency department by using age-stratified cut points.
.
Patient age (years) NT-proBNP values (pg/mL)
< 50 < 300 300 - 450  > 450
50 - 75 < 300 300 - 900 > 900
> 75 < 300 300 - 1,800 > 1,800
Interpretation

 
Acute HF unlikely

 
Acute HF less likely,
alternative causes
must be considered
Acute HF likely,
consider contounding
factors
NT-proBNP levels are affected by several factors other than acute CHF and those should therefore be incorporated into clinical decision making.  For example, NT-proBNP can be elevated in patients with acuye coronary syndrome (ACS), pulmonary embolism, shock, atrial arrhythmias, severe pneumonia, renal insufficiency or prior CHF

Reference:
Januzzi JL et al. Eur heart J 2006; 27:330-337; Heart Failure Society of America. J Card Fail 2006; 12:e1-2.
 
Clinical Reference (เอกสารอ้างอิง):
  1. Manufacturer’s Reagent package insert, Elecsys and cobas e analyzers ProBNP II, 2021-04,V.2 Roche Diagnostics GmbH, D-68305 Mannheim.         
  2. Reference range: Januzzi JL et al. Eur Heart J 2006; 27:330-337; Heart Failure Society of America. J Card Fail 2006; 12:e1-2.