Urine NGAL assay utilizes microparticles coated with monoclonal antibody for the detection of NGAL. Studies have shown that urinary NGAL is an early marker of Acute Kidney Injury (AKI) in a wide variety of settings. NGAL is one of the earliest proteins induced in the kidney after ischemic or nephrotoxic insult; studies have demonstrated elevated urine NGAL levels within two hours of insult. Early detection of NGAL may be used as an aid in the diagnosis of AKI and patient management.
Manufacturer’s Reagent package insert, Architect Urine NGAL, October 2015, Abbott Ireland, Diagnostics Division Lisnamuck, Longford Co. Longford Ireland.