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Test Code:
090-80-1080-01

Order Name:
Manganese (Blood)

 
Useful For:
  • Evaluation of central nervous system symptoms similar to Parkinson disease in manganese miners and processors
  • Characterization of liver cirrhosis
  • Therapeutic monitoring in treatment of cirrhosis, parenteral nutrition-related Mn toxicity and environmental exposure to Mn                
  • Evaluation of Behcet disease
 
Methodology:
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
 
AliasesName:
Mn (Manganese), Blood
 
 
 
Test Code:
090-80-1080-01

Order Name:
Manganese (Blood)

 
Collection Specimen Or Container:
Blood/ K2EDTA (Royal blue-top) 6 mL, 1 tube
 
Specimen Testing Type:
K2EDTA Whole blood, minimun 5 mL 
 
Sub Mission Container:
Plastic vial (PP Grade)
 
Rejection Criteria:
Hemolysis: 1+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
K2EDTA blood (keep in original tube) Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code:
090-80-1080-01

Order Name:
Manganese (Blood)

 
Method detail:
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
 
Schedule:
Tested on Tuesday and Friday at 7.00 a.m.
 
Turnaround Time:
Result reporting within Wednesday or Saturday, before 3.00 p.m.
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
1 month
 
 
 
Test Code:
090-80-1080-01

Order Name:
Manganese (Blood)

 
 
Clinical Information:
Manganese (II) ions function as cofactors for a large variety of enzymes with many functions. Manganese enzymes are particularly essential in detoxification of superoxide free radicals in organisms that must deal with elemental oxygen.While the element is a required trace mineral for all known living organisms, it also acts as a neurotoxin in larger amounts. Especially through inhalation, it can cause manganism, a condition in mammals leading to neurological damage that is sometimes irreversible.
 
Reference Value:
15.4 – 38.0 µg/L
 
Interpretation:
Manganese is an essential human dietary element. It is present as a coenzyme in several biological processes, which include macronutrient metabolism, bone formation, free radical defense systems.It is a critical component in dozens of proteins and enzymes. The human body contains about 12 mg of manganese, mostly in the bones. The soft tissue remainder is concentrated in the liver and kidneys. In the human brain, the manganese is bound to manganese metalloproteins, most notably glutamine synthetase in astrocytes.

Excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and symptoms similar to Parkinson's disease. The classes of enzymes that have manganese cofactors is large and includes oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, lectins, and integrins.
 
Clinical Reference:
  1. แสงโฉม เกิดคล้าย, บรรณาธิการ. แนวทางการวินิจฉัยเพื่อการรายงานโรคจากการประกอบอาชีพและ สิ่งแวดล้อม. พิมพ์ครั้งที่1. สำนักระบาดวิทยา กรมควบคุมโรค กระทรวงสาธารณสุข. สิงหาคม 2547:หน้า 22-33
  2. NCCLS document C38-A, Control of Pre analytical Variation in trace Element Determinations; Approved Guideline, 1997
  3. Biomarker Testing of Industrial Chemicals; Version 2018
  4. www.Thaitox.com
  5. The handbook of Environmental Chemistry Volume 3 Part A, Handbook on the toxicology of metals. Volume I., Ärztlicher Befundbericht, IMD Institut für Medizinische Diagnostik Berlin-Potsdam GbR, Nicolaistraße 22 - 12247 Berlin (Steglitz).
  6. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)
  7. K. Jomova, M. Valko, Advances in metal-induced oxidative stress and human disease, Toxicology 283 (2011) 65–87