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Test Code:
LD

Order Name:
Lactate Dehydrogenase (LDH)

 
Useful For:
Investigation of a variety of diseases involving the heart, liver, muscle, kidney, lung, and blood monitoring changes in tumor burden after chemotherapy, although, lactate dehydrogenase elevations in patients with cancer are too erratic to be of use in the diagnosis of cancer
 
Methodology:
Lactate to Pyruvate
 
AliasesName:
LD (Lactate Dehydrogenase), Blood
 
 
 
Test Code:
LD

Order Name:
Lactate Dehydrogenase (LDH)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: Mild or above reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 4 days
Frozen, -20o 1 month
 
 
 
Test Code:
LD

Order Name:
Lactate Dehydrogenase (LDH)

 
Method detail:
Lactate to Pyruvate
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
LD

Order Name:
Lactate Dehydrogenase (LDH)

 
 
Clinical Information:
LDH is an enzyme found in the cells of many body tissues, including the heart, liver, kidneys, skeletal muscle, brain, red blood cells, and lungs. It is responsible for converting muscle lactate into pyruvate, an essential step in producing cellular energy. It is composed of four peptide chains of two subunits (M form and H form) which results in up to five different isoenzymes which can be separated and quantitated by electrophoresis. Measurement of the total LDH activity in serum or plasma is non‑specific and cannot differentiate the tissues of origin of the component isoenzymes. LDH is used in the differential diagnosis of hemolytic anemia and as a tumor marker in some malignancies, such as germ cell tumors. LDH is elevated in hepatitis, glomerular nephritis, pulmonary embolism, muscle disease, and many leukemias and lymphomas. As LDH is a non-specific marker, it is used in combination with other markers in diagnosis and patient management.
 
Reference Value:
125 – 220 U/L
 
Interpretation:
Marked elevations in lactate dehydrogenase (LD) activity can be observed in megaloblastic anemia, untreated pernicious anemia, Hodgkin disease, abdominal and lung cancers, severe shock, and hypoxia. Moderate to slight increases in LD levels are seen in myocardial infarction (MI), pulmonary infarction, pulmonary embolism, leukemia, hemolytic anemia, infectious mononucleosis, progressive muscular dystrophy (especially in the early and middle stages of the disease), liver disease, and renal disease. In liver disease, elevations of LD are not as great as the increases in aspartate amino transferase (AST) and alanine aminotransferase (ALT). Increased levels of the enzyme are found in about one-third of patients with renal disease, especially those with tubular necrosis or pyelonephritis. However, these elevations do not correlate well with proteinuria or other parameters of renal disease. On occasion a raised LD level may be the only evidence to suggest the presence of a hidden pulmonary embolus.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® Lactate Dehydrogenase, Abbott Laboratories, Diagnostic Division, Abbott Park IL 60064 USA, November 2015.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)