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Overview Specimen Performance Clinical & Interpretation

Test Code:

090-71-5520

Order Name:

INVITAE Multi-Cancer Panel 84 genes (Diagnostic test) **

Useful For:

This panel may be considered for individuals with:

a personal or family history presenting with multiple cancer types that could fit the features of more than one hereditary cancer syndrome
a clinical history indicative of a hereditary cancer syndrome but a limited pedigree due to small family size or adoption

There are also some common general features suggestive of a family with a hereditary cancer syndrome. These include:

cancer diagnosed at an unusually young age
different types of cancer that have occurred independently in the same person
cancer that has developed in both organs of a set of paired organs (e.g., both kidneys, both breasts)
several close blood relatives that have the same type of cancer
unusual cases of a specific cancer type (e.g., male breast cancer)

Methodology:

Next-generation sequencing (NGS)

Test List In Profile:

Analyzes 84 genes:
AIP ALK APC ATM AXIN2 BAP1 BARD1 BLM BMPR1A BRCA1 BRCA2 BRIP1 CASR CDC73 CDH1 CDK4 CDKN1B CDKN1C CDKN2A CEBPA CHEK2 CTNNA1 DICER1 DIS3L2 EGFR EPCAM FH FLCN GATA2 GPC3 GREM1 HOXB13 HRAS KIT MAX MEN1 MET MITF MLH1 MSH2 MSH3 MSH6 MUTYH NBN NF1 NF2 NTHL1 PALB2 PDGFRA PHOX2B PMS2 POLD1 POLE POT1 PRKAR1A PTCH1 PTEN RAD50 RAD51C RAD51D RB1 RECQL4 RET RUNX1 SDHA SDHAF2 SDHB SDHC SDHD SMAD4 SMARCA4 SMARCB1 SMARCE1 STK11 SUFU TERC TERT TMEM127 TP53 TSC1 TSC2 VHL WRN WT1

AliasesName:

INVITAE 1 Panel Genetic Testing (Diagnostic test)

Test Code:

090-71-5520

Order Name:

INVITAE Multi-Cancer Panel 84 genes (Diagnostic test) **

Patient Preparation:

Genetics Counseling

Collection Specimen Or Container:

Blood/ K3 EDTA (Lavender Top) 6 mL, 1 tube

Document Require:
Completed Requesition Form (Select Multi-Cancer Panel)
& Completed Consent Form

Specimen Testing Type:

Blood/ K3 EDTA (Lavender Top) 6 mL, 1 tube

Sub Mission Container:

Whole blood EDTA, minimum volume 6 mL

Rejection Criteria:

Hemolyzed or clotted blood
Blood (or saliva) from patients who have had an allogeneic (non-self donor) bone marrow transplant
Blood (or saliva) from patients who have had an allogeneic (non-self donor) stem cell transplant
Blood (or saliva) from patients who had a blood transfusion less than two weeks prior to specimen collection

Specimen Stabillity:

Specimen Type	Temperature	Time
Whole blood EDTA	Refrigerated, 2^oC to 8^oC	14 days
Saliva (2mL) in special collection kit *	Ambient	30 days

* Optional, Nurse can request the special collection kit from Lab 4th Floor, Tel. 14160-2
** Sending to USA

Test Code:

090-71-5520

Order Name:

INVITAE Multi-Cancer Panel 84 genes (Diagnostic test) **

Method detail:

Next-generation sequencing (NGS)

Schedule:

N/A **Sent out to INVITAE, USA

Turnaround Time:

20-25 days

Performing Location:

INVITAE, USA
Referral Lab Services, Laboratory Department 14160-2

Test Code:

090-71-5520

Order Name:

INVITAE Multi-Cancer Panel 84 genes (Diagnostic test) **

Clinical Information:

The Invitae Multi-Cancer Panel analyzes 84 genes associated with hereditary cancers across major organ systems, including:

breast and gynecologic (breast, ovarian, uterine)
gastrointestinal (colorectal, gastric, pancreatic)
endocrine (thyroid, paraganglioma/pheochromocytoma, parathyroid, pituitary)
genitourinary (renal/urinary tract, prostate)
skin (melanoma, basal cell carcinoma)
brain/nervous system
sarcoma
hematologic (myelodysplastic syndrome/leukemia)

The Invitae Multi-Cancer Panel is designed to maximize diagnostic yield for individuals with a personal or family history of mixed cancers affecting multiple organ systems.

Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant would also guide testing and diagnosis of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

PTEN: Deletion/duplication analysis covers the promoter region.

Reference Value:

An interpretive report will be provided.

Clinical Reference: