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Test Code:
090-71-5552

Order Name:
INVITAE Cancer screen (Proactive test) **

 
Useful For:
Adult (อายุ 18 ปีขึ้นไป) who wants to optimize their health by knowing their personal genetic risk of cancer.  With that knowledge, action can be taken to prevent the onset of disease. 

If you checked "No" to all questions, your patient is likely a good candidate for Proactive genetic testing. If you checked "Yes" for any of the boxes above, you may want to consider further evaluation to determine whether Diagnostic testing is more appropriate for your patient.

Do any of the following apply to your patient or their close blood relative* ?
  • Early-onset breast cancer (at age 45 or younger), triple-negative breast cancer (ER-, PR-, HER2-; at age 60 or younger), breast cancer in a male, or breast cancer in an individual with Ashkenazi Jewish ancestry 
  • Ovarian cancer 
  • Colorectal cancer or endometrial cancer (younger than age 50) Diffuse gastric cancer 
  • Metastatic prostate cancer 
  • Pancreatic cancer 
  • 10 or more colon polyps 
*Close blood relatives include sibling, half-sibling, parent, child, aunt/uncle, niece/nephew, grandparent, or grandchild
 
Methodology:
Next-generation sequencing (NGS)
 
Test List In Profile:
APC ATM AXIN2 BAP1 BARD1 BMPR1A BRCA1 BRCA2 BRIP1 CDC73 CDH1 CDK4 CDKN2A CHEK2 DICER1 EPCAM FH FLCN GREM1 HOXB13 KIT MAX MEN1 MET MITF MLH1 MSH2 MSH3 MSH6 MUTYH NBN NF1 NF2 NTHL1 PALB2 PDGFRA PMS2 POLD1 POLE PRKAR1A PTCH1 PTEN RAD51C RAD51D RB1 RET SDHA SDHAF2 SDHB SDHC SDHD SMAD4 SMARCA4 SMARCB1 STK11 TMEM127 TP53 TSC1 TSC2 VHL WT1
 
 
 
Test Code:
090-71-5552

Order Name:
INVITAE Cancer screen (Proactive test) **

 
Patient Preparation:
Genetics Counseling 
ไม่ทำการตรวจ Proactive ในผู้ที่อายุต่ำกว่า 18 ปี 
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes

Document Require:
Completed Invitae Proactive Screen - Requesition & Consent Form
 
Specimen Testing Type:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes
 
Sub Mission Container:
Whole blood EDTA, minimum volume 6 mL
 
Rejection Criteria:
  • Hemolyzed or clotted blood
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) bone marrow transplant
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) stem cell transplant
  • Blood (or saliva) from patients who had a blood transfusion less than two weeks prior to specimen collection
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood EDTA Refrigerated, 2oC to 8oC 14 days
Saliva (2mL) in special collection kit * Ambient 30 days
* Optional, Nurse can request the special collection kit from Lab 4th Floor, Tel. 14160-2​
** Sending to USA
 
 
 
Test Code:
090-71-5552

Order Name:
INVITAE Cancer screen (Proactive test) **

 
Method detail:
Next-generation sequencing (NGS)
 
Schedule:
N/A **Sent out to Precision Health (INVITAE, USA)
 
Turnaround Time:
20-25 days
 
Performing Location:
Precision Health (INVITAE, USA)
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5552

Order Name:
INVITAE Cancer screen (Proactive test) **

 
 
Clinical Information:

The Invitae Cancer Screen analyzes more than 60 genes related to inherited cancers that, if detected early, may have effective medical interventions and preventive measures. Conditions tested include breast cancer, ovarian cancer, uterine cancer, colorectal cancer, cutaneous melanoma, gastric cancer, pancreatic cancer, prostate cancer, renal cell cancer, and thyroid cancer.

All genes included in the Cancer Screen can also be found in the Invitae Genetic Health Screen, which includes cardiovascular and cancer genes, as well as additional medically actionable conditions.

 
Reference Value:
An interpretive report will be provided.
 
Interpretation:
Report integrate relevant guidelines to help develop a personalized screening and prevention plan for patients.
 
Clinical Reference:
www.invitae.com (Retrieved: 29 Jun 2020)