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Test Code:
090-30-2700

Order Name:
IGFBP-3 (Blood)

 
Useful For:
  1. Measurement of insulin-like growth factor binding protein 3 (IGFBP-3) in serum.
  2. Aid in the evaluation of growth disorders. 
 
Methodology:
Chemiluminescent Immunometric assay
 
AliasesName:
Insulin-Like Growth Factor-Binding Protein 3, Blood
Insulin-Like Growth Factor-Binding Protein III, Blood
 
 
 
Test Code:
090-30-2700

Order Name:
IGFBP-3 (Blood)

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 24 hours
Frozen, -20oC 12 months
 
 
 
Test Code:
090-30-2700

Order Name:
IGFBP-3 (Blood)

 
Method detail:
Chemiluminescent Immunometric assay
 
Schedule:
Tested daily until 8:00 p.m.
 
Turnaround Time:
Collected specimen to reported within 1 day
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-2700

Order Name:
IGFBP-3 (Blood)

 
 
Clinical Information:
Insulin-like growth factors (IGF-1, IGF-11) are a family of peptides involved in the regulation of cell growth, the actions of which are mediated by binding to the insulin-like growth factor binding proteins. Six binding proteins (IGFBP-1 through IGFBP-6) have been described.5 IGFBP-3 is the most predominant of these.

IGFBP-3 is a 264-amino acid peptide (MW 29kD) which forms a 150kD glycoprotein complex consisting of
IGFBP-3 itself and an IGF molecule. Approximately 95% of IGF-1 and IGF-11 are bound to IGFBP-3, which makes this protein the major carrier of the insulin-like growth factors in circulation.The function of the binding protein is to extend the half-life of the growth factors in the circulation, to several hours.

IGFBP-3 is used as an aid in the evaluation of growth disorders. It is growth hormone (GH) dependent and therefore useful in the evaluation of GH secretion. 
 
Clinical Reference:
Manufacturer’s Reagent package insert, IMMULITE 2000 IGFBP-3 (PIL2KGB-15, 2018-03-15)