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Test Code:
IGF1

Order Name:
IGF-I

 
Useful For:
For the quantitative measurement of insulin-like growth factor I (IGF-1) in serum or heparinized plasma, as an aid in the evaluation of growth disorders.
 
Methodology:
Chemiluminescent Immunometric assay
 
AliasesName:
Insulin-Like Growth Factor-Binding Protein 1
 
 
 
Test Code:
IGF1

Order Name:
IGF-I

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 24 hours
Serum Refrigerated, 2oC to 8oC 24 hours
Frozen, -20oC 12 months
 
 
 
Test Code:
IGF1

Order Name:
IGF-I

 
Method detail:
Chemiluminescent Immunometric assay
 
Schedule:
Tested Daily until 8:00 p.m.
 
Turnaround Time:
Specimen collected to reported within 1 day
 
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
IGF1

Order Name:
IGF-I

 
 
Clinical Information:
In humans, plasma IGF-1 levels are barely detectable at birth, rise gradually during childhood, peak during mid-puberty until approximately 40 'tears of age, then decline gradually. Maternal plasma levels increase during pregnancy. In the diagnosis of growth disorders, measurements of IGF-1 are a useful indicator of growth hormone (GH) secretion. A normal plasma or serum IGF-1 concentration is strong evidence against GH deficiency. A low IGF-1 value implies GH deficiency and requires additional testing to determine whether GH secretion is subnormal. Measurement of IGF-1 is also useful in assessing change of nutritional status. 
 
Reference Value:
For Pediatric Reference Ranges (IGF-I, ng/mL)
Age, y Gender Median Central 95% Range
0-3 Male 44 < 15-129
4-6 Male 96 22-208
7-9 Male 132 40-255
10-11 Male 177 69-316
12-13 Male 305 143-506
14-15 Male 322 177-507
16-18 Male 284 173-414
0-3 Female 68 18-172
4-6 Female 105 35-232
7-9 Female 139 57-277
10-11 Female 248 118-448
12-13 Female 323 170-527
14-15 Female 317 191-496
16-18 Female 291 190-429

For Adult Reference Ranges (IGF-I, ng/mL)
Age, y Median Central 95% Range
19-21 207 117-323
22-24 175 99-289
25-29 160 84-259
30-34 136 71-234
35-39 126 63-223
40-44 122 58-219
45-49 120 53-215
50-54 108 48-209
55-59 108 45-210
60-64 112 43-220
65-69 110 40-225
70-79 92 35-216
80-90 94 31-208
 
For Tanner Stage Reference Ranges (IGF-I, ng/mL)
Tanner Stage Gender Median Central 95% Range
1 Male 144 63-271
2 Male 240 114-411
3 Male 298 166-510
4 Male 290 170-456
5 Male 257 161-384
1 Female 186 71-394
2 Female 288 122-508
3 Female 329 164-545
4 Female 319 174-480
5 Female 274 169-400
 
 
Clinical Reference:
Manufacturer’s Reagent package insert, IMMULITE 2000 IGF-I (PIL2KIGF-4, 2018-07-02)