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Test Code:
GGT

Order Name:
Gamma Glutamyltransferase (GGT)

 
Useful For:
Diagnosing and monitoring hepatobiliary disease, it is currently the most sensitive enzymatic indicator of liver disease. Ascertaining whether observed elevations of alkaline phosphatase are due to skeletal disease (normal gamma-glutamyltransferase: GGT) or reflect the presence of hepatobiliary disease (elevated GGT). A screening test for occult alcoholism.
 
Methodology:
L-Gamma-glutamyl-3-carboxy-4-nitroanilide Substrate
 
AliasesName:
Gamm GT
GGT
 
 
 
Test Code:
GGT

Order Name:
Gamma Glutamyltransferase (GGT)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 3+ or above reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20o 12 months
 
 
 
Test Code:
GGT

Order Name:
Gamma Glutamyltransferase (GGT)

 
Method detail:
L-Gamma-glutamyl-3-carboxy-4-nitroanilide Substrate
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
GGT

Order Name:
Gamma Glutamyltransferase (GGT)

 
 
Clinical Information:
Gamma-glutamyl transferase was first identified in kidney tissue. Even though renal tissue has the highest level of GGT, the enzyme present in serum appears to originate primarily from the hepatobiliary system, and GGT is elevated in many forms of liver disease. Elevations in GGT levels are seen earlier and are more pronounced than those with other liver enzymes in cases of obstructive jaundice and metastatic neoplasms. It may reach 5 to 30 times normal levels in intra- or post-hepatic biliary obstruction. Only moderate elevations in the enzyme level (2 to 5 times normal) are observed with infectious hepatitis: therefore, GGT measurements are less useful diagnostically than transaminase determinations with this condition.
 
Reference Value:
Male: 7– 65 U/L
Female: 7 – 50 U/L
 
Interpretation:
An elevation of gamma-glutamyltransferase (GGT) activity is seen in any and all forms of liver disease, although the highest elevations are seen in intra- or posthepatic biliary obstruction. Elevated values can also indicate alcoholic cirrhosis or individuals who are heavy drinkers. The finding of increased GGT and alkaline phosphatase (ALP) activity is consistent with hepatobiliary disease. The finding of normal GGT activity and increased ALP activity is consistent with skeletal disease.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® GAMMA-GLUTAMYL TRANSFERASE, ABBOTT Laboratories, Abbott Park IL 60064 USA, December 2012.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)