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Test Code:
G6PD

Order Name:
G-6-PD

 
Useful For:
The test is intended for use as a screening method for red cell glucose -6-phosephate dehydronase deficiency in newborns and adults.
 
Methodology:
Fluorescent Spot Test
 
AliasesName:
Glucose-6-phosphate dehydrogenase deficiency.
Hemolytic anemia
Favism hemolytic anemia
 
 
 
Test Code:
G6PD

Order Name:
G-6-PD

 
Collection Specimen Or Container:
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Blood, minimum volume 0.5 mL
 
Sub Mission Container:
Original tube
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, EDTA Refrigerated, 2oC to 8oC 3 days
 
 
 
Test Code:
G6PD

Order Name:
G-6-PD

 
Method detail:
Fluorescent Spot Test
 
Schedule:
Tested Daily (24 hours)
 
Turnaround Time:
Received specimen to report within 2 hours
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
G6PD

Order Name:
G-6-PD

 
 
Clinical Information:
Hemolytic disease may be associated with deficiency of erythrocyte enzymes. The most commonly encountered is a deficiency of glucose-6-phosphate dehydrogenase (G6PD).

The G6PD locus is on the X chromosome and, thus, G6PD deficiency is a sex-linked disorder. Affected males (hemizygotes) inherit the abnormal gene from their mothers who are almost always asymptomatic carriers (heterozygotes). More than 300 molecular variants of G6PD are known, and the clinical and laboratory features of G6PD deficiency vary accordingly. With some variants, there is chronic, life-long hemolysis, but much more commonly, the condition is asymptomatic and only results in susceptibility to acute hemolytic episodes, which may be triggered by some medications, ingestion of fava beans, viral, or bacterial infections.  It is also associated with neonatal  hyperbilirubinemia.

The major G6PD variants occur in specific ethnic groups. Thus, knowledge of the ethnic background of the patient is important. G6PD deficiency has very high frequency in Southeast Asians and is the most common cause of hemolytic disease of the newborn in Southeast Asian neonates.  It is also seen in persons of African and Mediterranean descent.
 
Reference Value:
Normal
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Instruction for use G-6-PD A Screening kit for Dried Blood Spots& Whole Blood Samples. R&D Diagnostics, Greece; ND03SQ-Jun.2016
  2. http://www.mayomedicallaboratories.com (Retrieved: 22 Jan 2019)