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Clear
 
Test Code:
090-30-1370-01

Order Name:
Dilantin (Phenytoin)* (Blood)

 
Useful For:
Used in the diagnosis and treatment of phenytoin overdose and in monitoring levels of phenytoin to help ensure appropriate therapy.
 
Methodology:
Enzyme immunoassay
 
AliasesName:
Phenytoin
Dilantin
 
 
 
Test Code:
090-30-1370-01

Order Name:
Dilantin (Phenytoin)* (Blood)

 
Patient Preparation:
Follow by Physician or Pharmacist recommedation.
 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 1 month
Frozen, -20oC 5 months
 
 
 
Test Code:
090-30-1370-01

Order Name:
Dilantin (Phenytoin)* (Blood)

 
Method detail:
Enzyme immunoassay
 
Schedule:
Tested daily (24 hours)
 
 
Turnaround Time:
Specimen collected to reported within 1:30 Hours (90 Mins)
 
Performing Location:
Biochemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-1370-01

Order Name:
Dilantin (Phenytoin)* (Blood)

 
 
Clinical Information:
Monitoring phenytoin concentrations, along with careful clinical assessment, is the most effective means of improving seizure control, reducing the risk of toxicity, and minimizing the need for additional anticonvulsant medication for the following reasons:
1. Phenytoin concentrations correlate better with pharmacologic activity than does dosage because of individual differences in absorption, metabolism, disease states, concomitant medication, and compliance. Concentration monitoring helps physicians individualize dosage regimens.
2. The hepatic enzyme system for metabolizing phenytoin can become saturated within the drug’s therapeutic range. When this occurs, small dosage alterations can lead to unexpected drug accumulation and clinical toxicity.
3. Phenytoin is safe and effective only in a narrow range of concentrations.
 
Reference Value:
Trough level: 10 - 20 µg/mL
 
Clinical Reference:
1. Manufacturer’s reagent package insert, Architect® Phenytoin, Microgenics Corporation 46500 Kato Road Fremont, CA 94538 USA, May 2015.