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Test Code:
DIG

Order Name:
Digoxin (Digitalis, Lanoxin), (Blood)

 
Useful For:
Measurement of digoxin in human serum.

Used to aid in the diagnosis and treatment of digoxin overdose and in monitoring levels of digoxin to help ensure appropriate therapy.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
Digitalis, Blood
Lanoxin, Blood
 
 
 
Test Code:
DIG

Order Name:
Digoxin (Digitalis, Lanoxin), (Blood)

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 2 days
Frozen, -20oC 6 months
 
 
 
Test Code:
DIG

Order Name:
Digoxin (Digitalis, Lanoxin), (Blood)

 
Method detail:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule:
Tested daily (24 hours)
 
 
Turnaround Time:
Specimen collected to reported within 2:00 hours (120 mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
DIG

Order Name:
Digoxin (Digitalis, Lanoxin), (Blood)

 
 
Clinical Information:
Digoxin is a potent cardiac glycoside prescribed for the treatment of patients suffering from congestive heart failure or from some types of cardiac arrhythmias. Monitoring of serum or plasma digoxin levels is performed because the drug has a low therapeutic ratio (a small difference between therapeutic and tissue toxic levels) and because the symptoms of drug overdose may resemble the original condition for which the drug was prescribed. Also, digoxin dosage may require adjustment when renal function is impaired or when drugs known to alter the pharmacokinetics of digoxin (e.g., quinidine, verapamil, or amiodarone) are coadministered.

Monitoring serum or plasma digoxin levels along with other clinical data can aid the physician in adjusting patient dosage to achieve optimal therapeutic effect while avoiding subtherapeutic or toxic dosage levels.
 
Reference Value:
Trough level: 0.8 - 2 ng/mL
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect iDigoxin, January 2015, Abbott Laboratories, MAXPlanck-Ring 65205 Wiesbaden, Germany
  2. Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com (Retrieved: July2018)