bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code:
090-40-1041-01

Order Name:
Cryptococcus Ag (Serum) *

 
Useful For:
Diagnosis of cryptococcosis
 
Methodology:
Latex Agglutination
 
AliasesName:
Cryptococcus Ag Screen,
Serum Cryptococcus gattii
Cryptococcus neoformans
Fungal Serology
 
 
 
Test Code:
090-40-1041-01

Order Name:
Cryptococcus Ag (Serum) *

 
Patient Preparation:
N/A
 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Room temperature, 18oC to 25oC 15 minutes
  Refrigerted, 2oC to 8oC 5 days
 
 
 
Test Code:
090-40-1041-01

Order Name:
Cryptococcus Ag (Serum) *

 
Method detail:
Latex Agglutination
 
Schedule:
Tested daily
 
Turnaround Time:
Received specimen to report within 3 hours.
 
Performing Location:
Microbiology, Laboratory Department Tel. 14171
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-40-1041-01

Order Name:
Cryptococcus Ag (Serum) *

 
 
Clinical Information:
Cryptococcosis is a systemic infection caused by the yeast, C. neoformans. The natural reservoirs for C. neoformans are soil and avian feces. Inhalation of yeast cells may lead to a lung infection and possibly disseminated disease. Patients often present with devastating debilitation, especially those with an immunosuppressive syndrome. Because C. neoformans has an unusual affinity for central nervous system tissue, rapid and early detection is essential. In 1963, Bloomfield reported detection of cryptococcal polysaccharide (CPS)antigens in serum and CSF of patients with cryptococcosis. In further testing, investigators reported false-positive reactions in the serum of patients with rheumatoid factor. In 1983, Stockman and Roberts introduced an enzymatic method incorporating protease to eliminate interference factors (e.g., rheumatoid factor) in serum. Such factors also include immune complexes, which have been shown to mask CPS antigen and prevent its recognition by sensitized latex particles. Since then, latex agglutination has been found to be a specific and sensitive method for rapid detection of CPS antigen in serum and CSF.
 
Reference Value:
Negative
 
Interpretation:
A positive result indicates the presence of CPS antigen in the patient specimen. A negative result indicates the absence of detectable levels of CPS antigen in the specimen.
 
Clinical Reference:
Manufacturer’s package insert, CALAS, Meridian Diagnostic, USA