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Clear
 
Test Code:
CR

Order Name:
Creatinine & eGFR (Blood)

 
Useful For:
Creatinine:
  • Diagnosing and monitoring treatment of acute and chronic renal diseases.
  • Adjusting dosage of renally excreted medications.
  • Monitoring renal transplant recipients.
Estimated Glomerular Filtration Rate (eGFR):
  • Serum creatinine measurement is used in estimating GFR for people with chronic kidney disease (CKD) and those with risk factors for CKD (diabetes, hypertension, cardiovascular disease, and family history of kidney disease)
 
Methodology:
Enzymatic
 
AliasesName:
Creatinine
eGFR
Estimated glomerular filtration rate
 
 
 
Test Code:
CR

Order Name:
Creatinine & eGFR (Blood)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject 
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20o 3 months
 
 
 
Test Code:
CR

Order Name:
Creatinine & eGFR (Blood)

 
Method detail:
Enzymatic
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
CR

Order Name:
Creatinine & eGFR (Blood)

 
 
Clinical Information:
Creatinine is eliminated from blood by glomerular filtration. Reduced renal function results in an increased serum creatinine concentration. Measurement of serum creatinine is used to diagnose and monitor acute and chronic renal disease, estimate glomerular filtration rate (GFR), or assess the status of renal dialysis patients. Urine creatinine analysis is used to calculate creatinine clearance, confirm completeness of 24-hour collections, or serve as a reference quantity for other analytes, such as in calculation of the albumin/creatinine ratio.
 
Reference Value:
Male : 0.73 –1.18 mg/dL
Female : 0.55 –1.02 mg/dL
 
Interpretation:
Creatinine: Because serum creatinine is inversely correlated with glomerular filtration rate (GFR), when renal function is near normal, absolute changes in serum creatinine reflect larger changes than do similar absolute changes when renal function is poor. For example, an increase in serum creatinine from 1 to 2 mg/dL may indicate a decrease in GFR of 50 mL/min (from 100 to 50 mL/min), whereas an increase in serum creatinine level from 4 to 5 mg/dL may indicate a decrease of only 5 mL/min (from 25 to 20 mL/min). Because of the imprecision of serum creatinine as an assessment of GFR, there may be clinical situations where a more accurate GFR assessment must be performed, iothalamate or inulin clearance are superior to serum creatinine and eGFR. Several factors may influence serum creatinine independent of changes in GFR. For instance, creatinine generation is dependent upon muscle mass. Thus, young, muscular males may have significantly higher serum creatinine levels than elderly females, despite having similar GFRs. Also, because some renal clearance of creatinine is due to tubular secretion, drugs that inhibit this secretory component (eg, cimetidine and trimethoprim) may cause small increases in serum creatinine without an actual decrease in GFR.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect ® Creatinine (enzymatic), SENTINEL CH.SpA Via Robert Koch, 2 Milan 20152, Italy, March 2017.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)