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Test Code:
090-20-1302-01

Order Name:
Chloride (U-24 hrs)

 
Useful For:
An indicator of fluid balance and acid-base homeostasis
 
Methodology:
Ion-selective electrode diluted (Indirect)
 
AliasesName:
Cl (Chloride), U-24 hrs.
 
 
 
Test Code:
090-20-1302-01

Order Name:
Chloride (U-24 hrs)

 
Collection Specimen Or Container:
24-hour urine, Clean containner with non preservative 

Note:
  • Please keep in refrigerated (2-8°C) during collection and transportation
  • 24-hours volume is required.
 
Specimen Testing Type:
24-hour urine, minimum volume 10 mL
 
Sub Mission Container:
Clean container
 
Specimen Stabillity:
Specimen Type Temperature Time
24-hours urine Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 7 days
 
 
 
Test Code:
090-20-1302-01

Order Name:
Chloride (U-24 hrs)

 
Method detail:
Ion-selective electrode diluted (Indirect)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-20-1302-01

Order Name:
Chloride (U-24 hrs)

 
 
Clinical Information:
Chloride is the major anion in the extracellular water space; its physiological significance is in maintaining proper body water distribution, osmotic pressure, and normal anion-cation balance in the extracellular fluid compartment.
Chloride is increased in dehydration, renal tubular acidosis (hyperchloremia metabolic acidosis), acute renal failure, metabolic acidosis associated with prolonged diarrhea and loss of sodium bicarbonate, diabetes insipidus, adrenocortical hyperfunction, salicylate intoxication, and with excessive infusion of isotonic saline or extremely high dietary intake of salt. Hyperchloremia acidosis may be a sign of severe renal tubular pathology.

Chloride is decreased in overhydration, chronic respiratory acidosis, salt-losing nephritis, metabolic alkalosis, congestive heart failure, Addisonian crisis, certain types of metabolic acidosis, persistent gastric secretion and prolonged vomiting, aldosteronism, bromide intoxication, syndrome of inappropriate antidiuretic hormone secretion, and conditions associated with expansion of extracellular fluid volume.
 
Reference Value:
110 – 250 mmol/24h
 
Interpretation:
Urine sodium and chloride excretion are similar and, under steady state conditions, both the urinary sodium and chloride excretion reflect the intake of sodium chloride (NaCl). During states of extracellular volume depletion, low values indicate appropriate renal reabsorption of these ions, whereas elevated values indicate inappropriate excretion (renal wasting). Urinary sodium and chloride excretion may be dissociated during metabolic alkalosis with volume depletion where urine sodium excretion may be high (due to renal excretion of NaHCO3) while urine chloride excretion remains appropriately low.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® ICT (Na+, K+, Cl-) Sample Diluent, Abbott Laboratories, Diagnostic Division, Abbott Park IL 60064, May 2016.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)