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Test Code:
092-10-0021

Order Name:
CYP2C9 and VKORC1 genotyping (3 SNPs - Fast track)

 
Useful For:
Identifying patients who may be at risk for altered metabolism of drugs that are modified by CYP2C9 and VKORC1. Predicting drug response to NSAID, Phenytoin and Warfarin.
 
Methodology:
Real-time PCR
 
AliasesName:
CYP2C9
VKORC1
pgx
Pharmacogenetics
Pharmacogenomics
 
 
 
Test Code:
092-10-0021

Order Name:
CYP2C9 and VKORC1 genotyping (3 SNPs - Fast track)

 
Collection Specimen Or Container:
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube, minimum volume 1.5 ml
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Use heparin as anticoagulant, Severe clotted specimen will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
EDTA Whole Blood Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
092-10-0021

Order Name:
CYP2C9 and VKORC1 genotyping (3 SNPs - Fast track)

 
Method detail:
Real-time PCR
 
Schedule:
Test Daily
 
Turnaround Time:
Received specimen to report within 3 days
 
Performing Location:
Research and Development, Tel. 14252
 
Specimen Retention Time:
3 months
 
 
 
Test Code:
092-10-0021

Order Name:
CYP2C9 and VKORC1 genotyping (3 SNPs - Fast track)

 
 
Clinical Information:
CYP2C9 and VKORC1 are an important drug metabolizing enzyme that catalyzes the biotransformation of warfarin. Inherited differences in VKORC1 increase or decrease the amount of warfarin needed to inhibit the formation of the clotting factors. When the amount of warfarin exceeds what is needed, the risk of bleeding is increased. This test identifies three common alleles in CYP2C9 (*1, *2, *3) and one common allele in VKORC1 by Real-time PCR. 
 
Clinical Reference:
Johnson JA, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharmacol Ther. 2017 Sep;102(3):397-404. doi: 10.1002/cpt.668. Epub 2017 Apr 4.