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Test Code:
CK

Order Name:
CPK

 
Useful For:
Diagnosing and monitoring myopathies or other trauma, toxin, or drug-induced muscle injury
 
Methodology:
NAC (N-acetyl-L-cysteine)
 
AliasesName:
CK
Creatine Kinase
 
 
 
Test Code:
CK

Order Name:
CPK

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: Mild or above reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
CK

Order Name:
CPK

 
Method detail:
NAC (N-acetyl-L-cysteine)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
CK

Order Name:
CPK

 
 
Clinical Information:
Measurements of creatine kinase are used in the diagnosis and treatment of diseases associated with skeletal muscle, heart, central nervous system, and thyroid.
 
Reference Value:
Male: 30 – 200 U/L
Female: 29 – 168 U/L
 
Interpretation:
Serum creatine kinase (CK) activity may increase in patients with acute cerebrovascular disease or neurosurgical intervention and with cerebral ischemia as well as in nearly all patients when injury, inflammation, or necrosis of skeletal or heart muscle occurs, including: - All types of muscular dystrophy particularly in progressive muscular dystrophy (particularly Duchenne sex-linked muscular dystrophy). - Viral myositis, polymyositis, and similar muscle diseases - Malignant hyperthermia, an inherited life-threatening condition characterized by high fever and brought on by administration of inhalation anesthesia - Muscle trauma, which causes CK elevations within 12 hours of onset, peaking within 1 to 3 days, and declining 3 to 5 days after cessation of muscle injury - Serum CK activities exceeding 200 times the upper reference limit may be found in acute rhabdomyolysis, putting the patient at great risk for developing acute renal failure. - When given at pharmacologic doses, some drugs including statins, fibrates, antiretrovirals, and angiotensin II receptor antagonists - Endocrine myopathy, for which hpothyroidism is a common cause, about 60% of hypothyroid subjects show an average elevation of CK activity 5-fold greater than the upper reference limit - Normal childbirth causes a 6-fold elevation in maternal serum For detection of myocardial infarction, changes in serum CK and its heart tissue (MB) isoenzyme have been largely replaced by the more cardiac-specific nonenzymatic markers, cardiac troponin I or T.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® Creatine Kinase, Abbott Laboratories, Diagnostic Division, Abbott Park IL 60064 USA, November 2015
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)