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Clear
 
Test Code:
HCGTOTAL

Order Name:
B-HCG*

 
Useful For:
Determination of beta human chorionic gonadotropin (β-hCG) in human serum  for the early detection of pregnancy.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
hCG (Human Chorionic Gonadotropins)
Beta-HCG (Human Chorionic Gonadotropin)
Human Chorionic Gonadotropins (hCG)
 
 
 
Test Code:
HCGTOTAL

Order Name:
B-HCG*

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 12 months
 
 
 
Test Code:
HCGTOTAL

Order Name:
B-HCG*

 
Method detail:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 hours (120 mins)
 
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
HCGTOTAL

Order Name:
B-HCG*

 
 
Clinical Information:
Human chorionic gonadotropin (hCG) is a sialoglycoprotein with a molecular weight of approximately 46,000 daltons. HCG is initially secreted by the trophoblastic cells of the placenta shortly after implantation of the fertilized ovum into the uterine wall. The rapid rise in hCG serum levels after conception makes it an excellent marker for early confirmation and monitoring of pregnancy.

Physiologically, hCG appears to maintain the corpus luteum, thereby allowing synthesis of progesterone and estrogens that support the endometrium. As uncomplicated pregnancies progress, the placenta assumes the production of these hormones. The serum hCG levels increase to a peak concentration, then decrease and plateau. HCG circulates as the intact molecule in the serum of normal women who have an uncomplicated pregnancy. The subunits are cleaved rapidly and cleared by the kidney. The placental hormone, hCG, is similar to luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH). All are
glycoproteins consisting of two noncovalently bound dissimilar subunits, designated alpha and beta, with attached carbohydrate sidechains. The alpha subunits of these glycoproteins are very similar. In contrast, the beta subunit portions determine the biological and immunochemical specificities.  The beta subunits of hCG and LH exhibit considerable homology in amino acid content. Amino acid residues specific for the beta subunit of hCG confer the immunochemical specificity. 

With the availability of sensitive quantitative assays for the measurement of serum β-hCG, it has been shown that hCG levels can be useful in prediction of spontaneous abortions, aiding in the detection of ectopic
pregnancy and multiple gestation.
 
Reference Value:
0 - 5 mIU/mL
 
Clinical Reference:
Manufacturer’s Reagent package insert Architect  Total β-hCG, March 2016, Abbott Ireland, Diagnostic Division Lisnamuck Longford Co., Ireland.