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Test Code:
090-70-8504

Order Name:
Anti nRNP  (ELISA method)

 
Useful For:
Diagnosis of a mix connective tissue disease (Sharp syndrome) in patients having signs and symptoms.
 
Methodology:
Enzyme-linked Immunosorbent Assay (ELISA)
 
AliasesName:
Anti U1RNP
Anti-Ribonuclear Protein
Anti-RNP (Anti-Ribonucleoprotein)
Anti-U1RNP (Anti-Ribonucleoprotein)
Autoantibodies to U1RNP
Ribonucleoprotein (RNP) Autoantibodies
U1RNP (Ribonucleoprotein) Autoantibodies
 
 
 
Test Code:
090-70-8504

Order Name:
Anti nRNP  (ELISA method)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross reject
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code:
090-70-8504

Order Name:
Anti nRNP  (ELISA method)

 
Method detail:
Enzyme-linked Immunosorbent Assay (ELISA)
 
Schedule:
Test daily, at 01:00 p.m.
 
Turnaround Time:
Received specimen to reported within 2 days.
 
Performing Location:
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-70-8504

Order Name:
Anti nRNP  (ELISA method)

 
 
Clinical Information:
Ribonucleoproteins (RNP) is composed of RNA and protein and is localised in the cell nucleus. The RNA components are described as U1 to U6 depending on their chromatographic behaviour. Apart from the individual RNA component, each U-n(nuclear)RNP particle displays six various core proteins (B, B', D, E, F, G). Antibodies against RNP in high titer and clinical symptom are use to diagnose Sharp syndrome (mixed connective tissue disease, MCTD). This syndrome is a multi-symptomatic and multiform mixed connective tissue disease combining symptoms of rheumatoid arthritis, SLE, systemic sclerosis, CREST syndrome and vasculitides.
 
Reference Value:
< 20 RU/mL
 
Interpretation:
Antibodies against RNP occur in approximately 50% of patients with lupus erythematosus (LE) and in patients with other connective tissue diseases, notably mixed connective tissue disease (MCTD). MCTD is characterized by high levels of RNP antibodies without detectable Sm or double-stranded DNA (dsDNA) antibodies. MCTD resembles LE but is not accompanied by renal involvement. High anti-nRNP/Sm titer are characteristic for Sharp syndrome, whereby the titer correlates with the disease activity. Anti-nRNP/Sm antibodies are also detected in patient with SLE, SSc and PM/DM.
 
Clinical Reference:
Manufacturer’s reagent package insert, Anti-nRNP/SM ELISA (IgG) Test instruction, February 2014, EUROIMMUN, D-23560 Lübeck Germany.