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Test Code:
ADNAA

Order Name:
Anti dsDNA ( Anti double stranded DNA ) by IFA

 
Useful For:
Diagnosis of systemic lupus erythematosus (SLE) in the suspected patient.
 
Methodology:
Indirect immunofluorescence assay
 
AliasesName:
Antibody to ds-DNA
Antibody to Native DNA (n-DNA)
Anti-DNA
Anti-ds (Anti-Double Stranded) DNA
ANTI-dsDNA ANTIBODY, IgG
DNA Double Stranded (ds-DNA) Antibody
 
 
 
Test Code:
ADNAA

Order Name:
Anti dsDNA ( Anti double stranded DNA ) by IFA

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: N/A
Lipemia: N/A
Icterus: N/A
Other: Heat-treated specimen will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code:
ADNAA

Order Name:
Anti dsDNA ( Anti double stranded DNA ) by IFA

 
Method detail:
Indirect immunofluorescence assay
 
Schedule:
Test daily, at 03:00 p.m.
 
Turnaround Time:
Specimen received to reported within 2 days.
 
Performing Location:
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
ADNAA

Order Name:
Anti dsDNA ( Anti double stranded DNA ) by IFA

 
 
Clinical Information:
Systemic lupus erythematosus is a systemic autoimmune disease belonging to the collagenosis group. Diagnosis of SLE is base on the 11 ACR criteria (ACR = American College of Rheumatology) . If 4 of 11 criteria are present, the probability of SLE presence is between 80 and 90%. Antibodies against dsDNA are among the most important criteria of diagnosis of SLE due to their high specificity: 70% to 98% depending on the method of detection. Since the concentration of these antibodies correlates with the disease activity, particularly with the activity of lupus nephritis, titer deteminations are suitable for monitoring therapy.
 
Reference Value:
Negative
 
Interpretation:
Anti-dsDNA antibodies are found almost exclusively in systemic SLE, also known as lupus erythematosus disseminatus. The prevalence of antibodies against dsDNA amounts to 20% to 90% depending on the detection method and disease activity. Antibodies against dsDNA are also occasionally detected in patient with other autoimmune diseases and infection and in rare cases, in clinically healthy people. 85% of people in the latter group develop SLE within 5 years of initial detection of anti-dsDNA. However, SLE cannot be entirely excluded if anti-dsDNA antibodies are not detected.
 
Clinical Reference:
Manufacturers’s package insert, Crithidia luciliae (anti-dsDNA) instructions for the indirect immunofluorescence test, January 2017, EUROIMMUN, D-23560 Lübeck Germany.