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Test Code:
090-30-1550-04

Order Name:
Anti-TG (Anti Thyroglobulin)

 
Useful For:
Determination of the IgG class of thyroglobulin autoantibodies (anti-Tg) in human serum.

Anti-Tg assay is intended for use as an aid in the diagnosis of autoimmune thyroid disease.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
Thyroglobulin Antibody
Anti-Thyroglobulin Antibody
TG (Thyroglobulin) Antibody
 
 
 
Test Code:
090-30-1550-04

Order Name:
Anti-TG (Anti Thyroglobulin)

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 3 days
Frozen, -20oC 30 days
 
 
 
Test Code:
090-30-1550-04

Order Name:
Anti-TG (Anti Thyroglobulin)

 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 hours (120 mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-1550-04

Order Name:
Anti-TG (Anti Thyroglobulin)

 
 
Clinical Information:
Autoimmune thyroiditis was first described by Hashimoto in 1912 and autoimmune thyroid disease with associated goitre is termed Hashimoto’s thyroiditis. The presence of anti-Tg in patients with this disease was first demonstrated in 1956 by Roitt, et al2 using a precipitin reaction. Unlike autoantibodies to thyroid peroxidase (anti-TPO), autoantibodies to thyroglobulin do not appear to be pathogenic and may simply be indicators of disease. They have been found to be polyclonal in nature and are also heterogeneous with respect to heavy chain subclass.

Thyroglobulin is a glycoprotein of 670,000 daltons, which is comprised of two identical subunits and represents the major protein found in the thyroid. This protein provides 40 tyrosine residues, of the 140 in the molecule, used for iodination during the biosynthesis of thyroxine (T4) and triiodothyronine
(T3) and, therefore, is responsible for the accumulation of iodine by the thyroid gland. Although anti-Tg are found in conjunction with anti-TPO in the majority of cases of Hashimoto’s thyroiditis, Primary Myxedema and Graves’ disease,up to 1% of cases of hypothyroidism are associated with anti-Tg alone. Anti-Tg are associated with cases of mild hypothyroidism or hyperthyroidism, and are frequently found in patients with other autoimmune diseases such as Rheumatoid Arthritis, Pernicious Anaemia and Type I Diabetes. Anti-Tg are detected in 30-60% of cases of thyroid carcinoma patients. In such patients, measurement of Tg antigen must take into account the likelihood of the presence of significant levels of anti-Tg, since measurement and detection of Tg antigen may be influenced by the presence of anti-Tg.

Furthermore, low levels of anti-Tg are also found in up to 20% of asymptomatic individuals, particularly the elderly and more often in women than men, although the clinical significance of these autoantibodies is unclear.
 
Reference Value:
< 4.11 IU/mL
 
Clinical Reference:
Manufacturer’s Reagent package insert Architect Anti-Tg, February 2015, Abbott Laboratories, Diagnostics Division, Abbott Park, IL 60064, USA.