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Clear
 
Test Code:
090-70-8503-01

Order Name:
Anti Smith  (ELISA method)

 
Useful For:
Diagnosis of a connective tissue disease in patients having signs and symptoms of the disease.
 
Methodology:
Enzyme-linked Immunosorbent Assay (ELISA)
 
AliasesName:
Anti-Smith (Sm) Antigen
Autoantibodies to Sm (Smith)
Sm (Anti-Sm) (Smith)
Sm (Smith) Autoantibodies
SmRNP Autoantibodies
 
 
 
Test Code:
090-70-8503-01

Order Name:
Anti Smith  (ELISA method)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross reject
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code:
090-70-8503-01

Order Name:
Anti Smith  (ELISA method)

 
Method detail:
Enzyme-linked Immunosorbent Assay (ELISA)
 
Schedule:
Test daily, at 01:00 p.m.
 
Turnaround Time:
Received specimen to reported within 2 days.
 
Performing Location:
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-70-8503-01

Order Name:
Anti Smith  (ELISA method)

 
 
Clinical Information:
Autoantibodies against SM can be directed against one or more ribonucleoproteins (small nuclear ribonucleoproteins, snRNP) and have a high specificity for SLE. Their detection fulfills a diagnostic criterion of the American College of Rheumatology (ACR) for SLE.
 
Reference Value:
< 20 RU/mL
 
Interpretation:
Antibodies against SM can be considered as pathognomonic for SLE, along with antibodies against dsDNA, nucleosomes and ribosomal P-protein. SM antibodies are detected in 5% to 40% of SLE patients. Whereas the prevalence in caucasians is approximately 10%, it is much higher in other ethnic groups, e.g. of Arabic, Chinese or Black African background. In American studies investigating a high proportion of non-caucasians, prevalences of 20% to 40% were found.
 
Clinical Reference:
Manufacturer’s reagent package insert, Anti-Sm ELISA (IgG) Test instruction, October 2016, EUROIMMUN, D-23560 Lübeck Germany.