Anti-HBc determinations can be used as an indicator of current or past HBV infection. Anti-HBc is found in serum shortly after the appearance of hepatitis B surface antigen (HBsAg) in acute HBV infections. It will persist after the disappearance of HBsAg and before the appearance of detectable antibody to HBsAg (anti-HBs).In the absence of information about any other HBV markers, it must be considered that an individual with detectable levels of anti-HBc may be actively infected with HBV or that the infection may have resolved, leaving the person immune.
Anti-HBc may be the only serological marker of HBV infection and potentially infectious blood. The presence of anti-HBc does not differentiate between acute or chronic hepatitis B infection.
Manufacturer’s Reagent package insert, Architect Anti-HBc II, January 2015, Abbott GmbH & Co. KG ,Max-Planck-Ring 2, 65205 Wiesbaden, Germany.