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Test Code (รหัสการทดสอบ):
CCP

Order Name (ชื่อการทดสอบ):
Anti-CCP (Cyclic Citrullinated Peptide Antibody)

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
 
Useful For (ประโยชน์การทดสอบ):
Determination of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in human serum.

Detection of anti-CCP antibodies is used as an aid in the diagnosis of Rheumatoid Arthritis (RA) and should be used in conjunction with other clinical information. Autoantibody levels represent one parameter in a multicriterion
diagnostic process, encompassing both clinical and laboratory-based assessments.
 
Methodology (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
Anti-Cyclic Citrullinated Peptide
Citrullinated Antibody
 
 
 
Test Code (รหัสการทดสอบ):
CCP

Order Name (ชื่อการทดสอบ):
Anti-CCP (Cyclic Citrullinated Peptide Antibody)

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 1 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: 4+ reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 24 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, - 20oC > 7 days
 
 
 
Test Code (รหัสการทดสอบ):
CCP

Order Name (ชื่อการทดสอบ):
Anti-CCP (Cyclic Citrullinated Peptide Antibody)

 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
CCP

Order Name (ชื่อการทดสอบ):
Anti-CCP (Cyclic Citrullinated Peptide Antibody)

 
 
Clinical Information (ข้อมูลทางคลินิก):
Rheumatoid Arthritis (RA) is a common, systemic autoimmune disease affecting 0.5-1% of the population. It is characterized by chronic inflammation of the synovium, which commonly leads to progressive joint
destruction and in most cases, to disability and reduction of quality of life. Evidence gained over the last few years suggests that aggressive therapy given early in the disease has the greatest therapeutic potential.

The serum of RA patients contains a variety of antibodies directed against self-antigens. The most widely known of these autoantibodies is the rheumatoid factor (RF) antibody directed against the constant domain of
IgG molecules. The presence of RF is one of the American College of Rheumatology’s (ACR) criteria for the classification of RA. Although the RF test has good sensitivity for RA, it is not very specific for the disease
as it can also be detected in the serum of patients with other rheumatic or inflammatory diseases and even in a substantial percentage of the healthy (elderly) population. For several years it has been recognized
that antibodies to anti-perinuclear factor (APF) and anti-keratin (AKA) are highly specific for RA. It was subsequently reported that both of these antibodies reacted with native filaggrin and are now referred to as
anti-filaggrin antibodies (AFA). More recently it has been shown that all of these antibodies are directed to citrulline-containing epitopes. Citrulline is a non-standard amino acid, as it is not incorporated into proteins during protein synthesis. It can, however, be generated via post-translational modification of arginine residues by the enzyme peptidyl arginine deiminase (PAD). In 1998, Schellekens and colleagues reported that linear peptides containing citrulline (CP) were very specific for RA antibodies (96%) in an ELISA based assay. Subsequent work demonstrated that cyclic variants of these peptides, termed cyclic citrullinated peptides (CCP), were equally specific for RA, but with a higher sensitivity than linear peptides.  To improve the sensitivity of the CCP test further, several dedicated libraries of citrulline-containing peptides were screened with RA sera and a new set of peptides (CCP2) were discovered which gave superior performance compared to the CCP1 test. Over the last few years, many independent studies have confirmed the diagnostic performance of the CCP2 test.

In 2007, the European League against Rheumatism (EULAR) published guidelines for the diagnosis of early RA, and the measurement of antibodies to anti-CCP was included as a serology marker.
 
Reference Value (ค่าอ้างอิง):
< 5.0 U/mL
 
Clinical Reference (เอกสารอ้างอิง):
Manufacturer’s Reagent package insert, Anti-CCP,  Abbott Max-Planck-Ring 2, 65205 Wiesbaden, Germany.