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Test Code (รหัสการทดสอบ):
LBCHAMIK

Order Name (ชื่อการทดสอบ):
Amikacin

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 1.5 hours (90 mins)
 
Useful For (ประโยชน์การทดสอบ):
Intended for the quantitative determination of amikacin in human serum or plasma. The results obtained are used in the diagnosis and treatment of amikacin overdose and in monitoring levels of amikacin to help ensure appropriate therapy.
 
Methodology (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition Immunoassay (PETINIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
Amikin
 
 
 
Test Code (รหัสการทดสอบ):
LBCHAMIK

Order Name (ชื่อการทดสอบ):
Amikacin

 
Patient Preparation (การเตรียมตัวผู้ป่วย):
Follow the instruction of physician and pharmarcist.
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: Mild reject
Lipemia: 4+ reject
Icterus: 3+ reject
Other: N/A
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Serum Frozen, -20oC 14 days
 
 
 
Test Code (รหัสการทดสอบ):
LBCHAMIK

Order Name (ชื่อการทดสอบ):
Amikacin

 
Method detail (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition Immunoassay (PETINIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 Hours)
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
LBCHAMIK

Order Name (ชื่อการทดสอบ):
Amikacin

 
 
Clinical Information (ข้อมูลทางคลินิก):
Amikacin is a semi-synthetic aminoglycoside that exhibits bactericidal activity against a wide range of pathogens, including many organisms resistant to other aminoglycosides. Amikacin is active in vitro against gram-negative organisms, penicillinase, and non-penicillinase producing staphylococci. The strength of this drug is due primarily to its high degree of resistance to aminoglycoside-inactivating enzymes. Determination of serum or plasma drug levels is required to achieve optimum therapeutic efficacy and minimize toxicity.
 
Reference Value (ค่าอ้างอิง):
Peak values: 25-35 µg/mL
Trough values: 4-8 µg/mL
 
Interpretation (การแปลผล):
Although optimum values may vary, periodic measurements of both peak and trough concentrations of amikacin are recommended to ensure adequate drug levels and prevent toxic side effects.  The most serious toxic effect is permanent damage to the vestibular division of the eighth cranial nerve, which has been reported to occur most frequently in patients with renal failure. Amikacin is inherently stable, is not metabolized, and is excreted primarily by glomerular filtration.

Therefore, the presence of renal impairment drastically alters its pharmacokinetics. If dosage regimens are not drastically adjusted, excess accumulation leading to ototoxicity and further renal impairment could be encountered. While elevated serum levels can be toxic, indiscriminately low dosages of amikacin will result in ineffective treatment for many strains of gram-negative bacteria. Organisms which are resistant to amikacin will often show increased resistance to all other available aminoglycosides. This observation points out the possibility that the indiscriminate use of low dosages of amikacin could engender the emergence of drug-resistant organisms and possibly render the drug ineffective in treating infectious disease.  

Each laboratory should investigate the transferability of the expected values to its own patient population and, if necessary, determine its own therapeutic range.
 
Clinical Reference (เอกสารอ้างอิง):
  1. Manufacturer’s reagent package insert, Architect Amikacin,  Microgenics Corporation, 46500 Kato Road, Fremont, CA 94538, USA, October 2016.
  2. Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com (Retrieved: July 2018)
  3. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)