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Test Code:
090-30-2090-01

Order Name:
Acetaminophen (Paracetamol)

 
Useful For:
 Used in the diagnosis and treatment of acetaminophen overdose toxicity.
 
Methodology:
Enzymatic/ Colorimetric
 
AliasesName:
Paracetamol
Tylenol 
 
 
 
Test Code:
090-30-2090-01

Order Name:
Acetaminophen (Paracetamol)

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Room temperature, 20oC to 28oC 8 hours
Serum Refrigerated, 2oC to 8oC 14 days
Frozen, -20oC 45 days
 
 
 
Test Code:
090-30-2090-01

Order Name:
Acetaminophen (Paracetamol)

 
Method detail:
Enzymatic/ Colorimetric
 
Schedule:
Tested Daily (24 Hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department
Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-2090-01

Order Name:
Acetaminophen (Paracetamol)

 
 
Clinical Information:
Acetaminophen (paracetamol) is used as an analgesic in many different
formulations. While therapeutic doses rarely cause adverse side effects, the effect
of long term treatment with acetaminophen is unclear. Cases have been reported
where chronic excessive use of acetaminophen has led to hepatotoxicity and
nephrotoxicity. In cases of acute overdosage, acetaminophen can cause severe
hepatic damage leading to hepatic failure if untreated.
The management of acetaminophen overdose requires early recognition of the drug in the bloodstream. Toxicity is generally reported at concentrations over 200 μg/mL(1324 μmol/L). N-acetylcysteine has been used as an antidote in conjunction with intensive support care. Early diagnosis of acetaminophen-induced hepatotoxicity is important since initiation of therapy within 8 hours of ingestion lessens the potential for hepatic injury and decreases the mortality rate.
The majority of methods for measuring acetaminophen are based on spectrophotometric or chromatographic principles. Chromatographic methods are specific for the parent compound; however, they are not well suited to emergency laboratories. Spectrophotometric methods are simpler and more rapid, but do not always offer the desired specificity.
 
Reference Value:
Therapeutic concentration: < 30µg/mL
Acetaminophen level is usually drawn after 4 hours of ingestion of acetaminophen
Toxic: ≥ 150 µg/mL 4 hours after dose
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, SEKURE™CHEMISTRY ACETAMINOPHEN L3K® Sekisui Diagnostics (UK) Limited, Liphook Way, Allington, Maidstone KENT, ME16 0LQ, UK., January 20, 2016.
  2. Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. www.uptodate.com/contents/acetaminophen-paracetamol-poisoning-in-adults-pathophysiologypresentation-and-diagnosis (Retrieved: Jul 2018)