bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code:
092-10-0024

Order Name:
APOE genotype (for Cardiovascular Disease)

 
Useful For:
Identifying patients who may be at risk for altered cholesterol metabolism and transportation. This event has associated with increase the risk for cardiovascular disease.
 
Methodology:
Real-time PCR
 
Test List In Profile:
APOE Alleles e2, e3 and e4
 
AliasesName:
Apolipoprotein E genotyping
APOE
 
 
 
Test Code:
092-10-0024

Order Name:
APOE genotype (for Cardiovascular Disease)

 
Collection Specimen Or Container:
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube, minimum volume 1.5 ml
 
Sub Mission Container:
K3 EDTA (K3E) (Lavender Top)
 
Rejection Criteria:
Use heparin as anticoagulant.
Severe clotted specimen.
 
Specimen Stabillity:
Specimen Type Temperature Time
EDTA whole blood Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
092-10-0024

Order Name:
APOE genotype (for Cardiovascular Disease)

 
Method detail:
Real-time PCR
 
Turnaround Time:
Reported within 7-10 days
 
Performing Location:
Clinical Genomics Tel. 14252
 
Specimen Retention Time:
3 months
 
 
 
Test Code:
092-10-0024

Order Name:
APOE genotype (for Cardiovascular Disease)

 
 
Clinical Information:
Apolipoprotein E (ApoE) locates on 19q13.2 and consists of 299 amino in length. It plays an important role in cholesterol transportation and metabolism. Three most common alleles of ApoE are e3 (Cys112/Arg158), e2(Cys112/Cys158) and e4(Arg112/Arg158). Among these three alleles, e3 is the wildtype and most commonly found. Mutation in ApoE might increase or decrease the risk for cardiovascular disease. 
 
Reference Value:
Wild-type of APOE gene (e3/e3)
 
Clinical Reference:
  1. Mendelian Inheritance in Man’ (OMIM) Apolipoprotein E; APOE −107741 [Internet]. OMIM. 2016 [cited 16 March 2021]. Available from: https://omim.org/entry/107741.
  2. Mahley RW. Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. J Mol Med (Berl). 2016;94(7):739-46.