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Test Code:
090-81-2010

Order Name:
Thiopurine Metabolites, Whole Blood **

 
Useful For:
A first-order test for the laboratory diagnosis of myasthenia gravis (MG) Monitoring disease progression in MG or response to immunotherapy
 
Methodology:
Radioimmunoassay (RIA)
 
AliasesName:
ACh Receptor (Muscle) Binding Ab
Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum
Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
Anti -Neuromuscular Junction Receptor Antibodies
Myasthenia Gravis Antibodies
 
 
 
Test Code:
090-81-2010

Order Name:
Thiopurine Metabolites, Whole Blood **

 
Patient Preparation:
This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled if radioactivity remains.
 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Specimen Testing Type:
Serum, minimum volume 2 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross reject
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Ambient 72 hours
Refrigerated, 2oC to 8oC (preferred) 28 days
Frozen 28 days
 
 
 
Test Code:
090-81-2010

Order Name:
Thiopurine Metabolites, Whole Blood **

 
Method detail:
Radioimmunoassay (RIA)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to report within 14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-81-2010

Order Name:
Thiopurine Metabolites, Whole Blood **

 
 
Clinical Information:
Myasthenia gravis (MG) is characterized by weakness and easy fatigability that are relieved by rest and anticholinesterase drugs. The weakness in most cases results from an autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the postsynaptic membrane of skeletal muscle. Demonstration of muscle AChR autoantibodies in a patient's serum supports the diagnosis of acquired (autoimmune) MG, and quantitation provides a baseline for future comparisons.
 
Reference Value:
< or = 0.02 nmol/L
 
Interpretation:
Values above 0.02 nmol/L are consistent with a diagnosis of acquired myasthenia gravis (MG), provided that clinical and electrophysiological criteria support that diagnosis.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 24 Jan 2019)