bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code:
FLC

Order Name:
Serum Free Light Chain **

 
Useful For:
Monitoring patients with monoclonal light chain diseases but no M-spike on protein electrophoresis (Monoclonal Gammopathy)
 
Methodology:
Nephelometry
 
Test List In Profile:
Free Kappa
Free Lambda
Kappa: Lambda Ratio
 
AliasesName:
Immunoglobulin Free Light Chains, Serum
FLC
Free Light Chain
 
 
 
Test Code:
FLC

Order Name:
Serum Free Light Chain **

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 2 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Hemolysis interfere
Lipemia: Mild OK; Gross reject
 
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Room temperature (preferred), 18oC to 25oC 3 days
Refrigerated, 2oC to 8oC 28 day
 
 
 
Test Code:
FLC

Order Name:
Serum Free Light Chain **

 
Method detail:
Nephelometry
 
Schedule:
N/A **Sent Out to Siriraj
 
Turnaround Time:
Reported within 7 days (exception for official holidays)
 
Performing Location:
Siriraj
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
FLC

Order Name:
Serum Free Light Chain **

 
 
Clinical Information:
The monoclonal gammopathies include multiple myeloma (MM), light chain multiple myeloma (LCMM), Waldenstrom macroglobulinemia (WM), nonsecretory myeloma (NSMM), smoldering multiple myeloma (SMM), monoclonal gammopathy of undetermined significance (MGUS), primary systemic amyloidosis (AL), and light chain deposition disease (LCDD). Monoclonal proteins are typically detected by serum protein electrophoresis (SPEP) and immunofixation (IF). However, the monoclonal light chain diseases (LCMM, AL, LCDD) and NSMM often do not have serum monoclonal proteins in high enough concentration to be detected and quantitated by SPEP. A sensitive nephelometric assay specific for kappa free light chain (FLC) and lambda free light chain (FLC) that doesn't recognize light chains bound to Ig heavy chains has recently been described. This automated, nephelometric assay is reported to be more sensitive than IF for detection of monoclonal FLC. In some patients with NSMM, AL, or LCDD the FLC assay provides a positive identification of a monoclonal serum light chain when the serum IF is negative. In addition, the quantitation of FLC has been correlated with disease activity in patients with NSMM and AL.
 
Reference Value:
Test Reference Value Unit
Free Kappa 3.30 - 19.40 mg/L
Free Lambda 5.71 - 26.30 mg/L
Kappa:Lambda Ratio 0.26 - 1.69 -
 
Interpretation:
Once an abnormal free light chain (FLC) K/L ratio has been demonstrated and a diagnosis has been made, the quantitation of the monoclonal light chain is useful for monitoring disease activity.
 
Clinical Reference:
  1. www.si.mahidol.ac.th (Retrieved: 23 Jan 2019) 
  2. www.mayomedicallaboratories.com (Retrieved: 23 Jan 2019)