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Test Code (รหัสการทดสอบ):
092-10-0039

Order Name (ชื่อการทดสอบ):
SNP genotyping for Allergy genetic panel

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube

Document required
Consent for Genetic Testing (LAB-08171)
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 7-10 days
 
Useful For (ประโยชน์การทดสอบ):
This allergy genetic panel test provides information on the risk associated with allergy conditions including the allergy-induced by food and allergy that may affect one’s breathing conditions and skin conditions. 

This screening test could help determine the risks of allergies induced by food including peanut allergy and lactose intolerance, an allergy that affects breathing conditions including early childhood asthma, wheezing, and adult onset of asthma and chronic obstructive pulmonary disease (COPD), and allergy that affect skin conditions including atopic dermatitis and ichthyosis vulgaris.  
 
Methodology (วิธีการทดสอบ):
Real-time PCR
 
AliasesName (ชื่อเรียกอื่นๆ) :
Allergy
Allergy genetic
SNP genotyping
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0039

Order Name (ชื่อการทดสอบ):
SNP genotyping for Allergy genetic panel

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube

Document required
Consent for Genetic Testing (LAB-08171)
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Original tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Use heparin as anticoagulant,
Severe clotted specimen will be reject.
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
EDTA Whole Blood Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0039

Order Name (ชื่อการทดสอบ):
SNP genotyping for Allergy genetic panel

 
Method detail (วิธีการทดสอบ):
Real-time PCR
 
Schedule (ตารางการทดสอบ):
Test Daily
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 7-10 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Research and Development, Tel. 14252
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
3 months
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0039

Order Name (ชื่อการทดสอบ):
SNP genotyping for Allergy genetic panel

 
 
Clinical Information (ข้อมูลทางคลินิก):
SNP genotyping for allergy genetic panel is a genetic testing for five single nucleotide polymorphisms (SNPs). This test is a screening tool to determine the risks for peanut allergy, lactose intolerance, early childhood asthma, wheezing, and adult onset of asthma and COPD, atopic dermatitis, and ichthyosis vulgaris. The interpretation of peanut allergy is based on intergenic SNP between HLA-DQB1 & HLA-DQA2 (rs9275596; T>C) and HLA-DRA (rs7192; G>T). The interpretation of lactose intolerance is based on MCM6 (rs4988235; G>A). The interpretation of early childhood asthma, wheezing, and adult onset of asthma and COPD are based on CDHR3 (rs6967330; G>A). The interpretation of atopic dermatitis, and ichthyosis vulgaris are based on FLG (rs61816761; G>A).
 
Clinical Reference (เอกสารอ้างอิง):
  1. Hong X, et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
  2. Baffour-Awuah NY, et al. Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr. 2015 Feb;60(2):182-91. 
  3. Bønnelykke K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014 Jan;46(1):51-5.
  4. Basnet S, et al. CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C Infections. Am J Respir Cell Mol Biol. 2019 Oct;61(4):450-458.
  5. Everman JL. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. J Allergy Clin Immunol. 2019 Oct;144(4):962-971. 
  6. Leung TF, et al. Cadherin-related family member 3 gene impacts childhood asthma in Chinese children. Pediatr Allergy Immunol. 2020 Feb;31(2):133-142.
  7. Shigemasa R, et al. Genetic impact of CDHR3 on the adult onset of asthma and COPD. Clin Exp Allergy. 2020 Nov;50(11):1223-1229.
  8. Wong XFCC, et al. Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants. J Allergy Clin Immunol. 2018 Feb; 141(2): 814–816.