Genital herpes caused by HSV is one of the most common sexually transmitted diseases. HSV primary infection or reactivation of latent disease can cause cutaneous or mucosal lesions. These lesions are usually self-limited but severe disease can occur in compromised patients, pregnant woman and infants. Encephalitis is inflammation of the brain associated with clinical evidence of neurologic dysfunction. Of the pathogens reported to cause encephalitis, the majority are viruses. HSV causes about 5–10% of all encephalitis cases, and is one of the most common causes of identified sporadic encephalitis globally. HSV encephalitis occurs in all ages, and during all seasons. Clinical features involved with HSV encephalitis include fever, hemicranial headache, language and behavioral abnormalities, memory impairment, and seizures. The diagnosis of herpes virus relies predominately on culture or direct fluorescent antibody (DFA) staining methods. However, these methods are labor intensive, time consuming, and subjective. Rapid and accurate testing for HSV infection utilizing molecular detection can be critical for both therapeutic decision-making and infection control.
Manufacturer’s packages insert, Simplexa™ HSV 1 & 2 Direct Rev. E, August 2015, Focus Diagnostics, CA 90630 Cypress, USA.