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Overview Specimen Performance Clinical & Interpretation

Test Code:

092-10-0009

Order Name:

Oncomine™ Pan‑Cancer Cell‑Free Panel (Fast track)

Useful For:

The detection of relevant SNVs, CNVs, gene fusions, and indels from 52 unique genes to help inform drug discovery research and clinical trial research programs.

Gene List:
- Full-length genes:
  APC, FBXW7, PTEN, TP53

- Hotspot genes:
AKT1, ALK, AR, ARAF, BRAF, CHEK2, CTNNB1, DDR2,EGFR, ERBB2, ERBB3, ESR1, FGFR1,
  FGFR2, FGFR3, FGFR4, FLT3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MAP2K1,
  MAP2K2, MET, MTOR, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, RAF1, RET, ROS1, SF3B1,
  SMAD4, SMO

- Copy number variations genes (CNVs):
  CCND1, CCND2, CCND3, CDK4, CDK6, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, MET, MYC

- Gene fusions:
  ALK, BRAF, ERG, ETV1, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK3, RET, ROS1

Methodology:

Next generation sequencing (NGS), Target sequencing

AliasesName:

Cell-free DNA
cfDNA
ctDNA
Liquid biopsy

Test Code:

092-10-0009

Order Name:

Oncomine™ Pan‑Cancer Cell‑Free Panel (Fast track)

Collection Specimen Or Container:

Blood/ Streck 10 mL, 2 tubes

Specimen Testing Type:

Whole blood 10 mL Streck tube, 2 tubes

Sub Mission Container:

Streck tube

Specimen Stabillity:

Specimen Type	Temperature	Time
Whole blood	Ambient temperature	7 days

Test Code:

092-10-0009

Order Name:

Oncomine™ Pan‑Cancer Cell‑Free Panel (Fast track)

Method detail:

Next generation sequencing (NGS), Target sequencing

Turnaround Time:

Reported within 14 days

Performing Location:

Research and Development Tel. 14252

Specimen Retention Time:

1 day

Test Code:

092-10-0009

Order Name:

Oncomine™ Pan‑Cancer Cell‑Free Panel (Fast track)

Clinical Information:

The Oncomine^TM Pan-Cancer Cell-Free Panel detect multiple mutations in tumor-derived DNA and RNA isolated from the plasma fraction of whole blood. These 52 genes have been identified as frequently mutated in multiple cancer types, including: bladder, brain and CNS, breast, cervical, colorectal, endometrial, esophageal, gastric, head and neck, kidney, liver, lung, melanoma, ovarian, pancreatic, prostate, sarcoma, and thyroid.

Clinical Reference:

https://www.thermofisher.com/order/catalog/product/A37664 (Retrieved 1 Feb 2019)