Clinical Information (ข้อมูลทางคลินิก):
Magnesium is an essential nutrient which is involved in many biochemical functions. It has a structural role in nucleic acids and ribosomal particles, required as an activator for many enzymes and has a role in energy producing oxidative phosphorylation.
The normal body contains between 21 to 28 g magnesium, more than 50% of which is complexed with calcium and phosphate in bone. Only approximately 1% of the total magnesium is found in the extracellular fluid; hence, it tends to enter and leave cells under the same conditions as potassium. Approximately 35% of plasma magnesium is protein-bound, mainly to albumin, and therefore changes in albumin concentration may affect magnesium.
Hypomagnesemia results in the impairment of neuromuscular function and may develop in severe prolonged diarrhea, malabsorption syndromes, hyperaldosteronism, and diuretic therapy. Hypermagnesemia is seen in renal glomerular failure and diabetic coma.
Symptoms of magnesium deficiency do not typically appear until low level.
Levels of very high may be life-threatening.