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Clear
 
Test Code:
090-40-1064

Order Name:
Legionella pneumophila Antigen (Urine)

 
Useful For:
An adjunct to culture for the presumptive diagnosis of past or current Legionnaires disease (Legionella pneumophila serogroup 1)
 
Methodology:
Immunochromatographic Membrane Assay
 
AliasesName:
Legionella pneumophila
Legionellosis Legionnaires' Disease
 
 
 
Test Code:
090-40-1064

Order Name:
Legionella pneumophila Antigen (Urine)

 
Collection Specimen Or Container:
Urine/ Sterile container (or urine clean container)
 
Specimen Testing Type:
Random Urine, minimum volume 2 mL.
 
Sub Mission Container:
Sterile container or urine container
 
Specimen Stabillity:
Specimen Type Temperature Time
Random urine Room temperature, 18oC to 25oC 24hours
Refrigerated, 2oC to 8oC 14 days
Frozen, -20oC (preferred) 14 days
 
 
 
Test Code:
090-40-1064

Order Name:
Legionella pneumophila Antigen (Urine)

 
Method detail:
Immunochromatographic Membrane Assay
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Received specimen to report within 1 hour.
 
Performing Location:
Microbiology, Laboratory Department Tel. 14171
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-40-1064

Order Name:
Legionella pneumophila Antigen (Urine)

 
 
Clinical Information:
Legionnaires’ disease, named after the outbreak in 1976 at the American Legion convention in Philadelphia, is caused by Legionella pneumophila and is characterized as an acute febrile respiratory illness ranging in severity from mild illness to fatal pneumonia. Since that time, it has been recognized that the disease occurs in both epidemic and endemic form and that sporadic cases are not readily differentiated from other respiratory infections by clinical symptoms. It is estimated that about 25,000 cases of Legionella infections occur annually. Known risk factors include immunosuppression, cigarette smoking, alcohol consumption and concomitant pulmonary disease. The resulting mortality rate, which ranges up to 25% in untreated immunocompetent patients, can be lowered if the disease can be diagnosed rapidly and appropriate antimicrobial therapy is instituted early. Legionella pneumophila is estimated to be responsible for 80-85% of reported cases of Legionella infections with the majority of cases being caused by L. pneumophila serogroup 1 alone
 
Reference Value:
Negative
 
Interpretation:
Positive Presumptive positive for Legionella pneumophila serogroup 1 antigen in urine, suggesting current or past infection. Culture is recommended to confirm infection. Negative Presumptive negative for L pneumophila serogroup 1 antigen in urine, suggesting no recent or current infection. Infection with Legionella cannot be ruled out because: -Other serogroups (other than serogroup 1, which is detected by this assay) and other Legionella species (other than L pneumophila) can cause disease -Antigen may not be present in urine in early infection -The level of antigen may be below the detection limit of the test Legionella culture is recommended for cases of suspected Legionella pneumonia due to organisms other than L pneumophila serogroup 1.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert BinaxNOW® Legionella Urinary Antigen test;PN IN851050 Rev.5 2018/07 Binax, Inc. 10 Southgate Road, Scarborough, Maine, USA
  2. https://www.mayocliniclabs.com (Retreived: 29 Jan 2019)