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Test Code:
090-71-5524

Order Name:
INVITAE Genetic health screen (Proactive test) **

 
Useful For:
Determine a healthy adult's predisposition to cancer, cardiovascular conditions, and more.

If you checked "No" to all questions, your patient is likely a good candidate for Proactive genetic testing. If you checked "Yes" for any of the boxes above, you may want to consider further evaluation to determine whether Diagnostic testing is more appropriate for your patient.

Do any of the following apply to your patient or their close blood relative* ?
  • Early-onset breast cancer (at age 45 or younger), triple-negative breast cancer (ER-, PR-, HER2-; at age 60 or younger), breast cancer in a male, or breast cancer in an individual with Ashkenazi Jewish ancestry 
  • Ovarian cancer 
  • Colorectal cancer or endometrial cancer (younger than age 50) Diffuse gastric cancer 
  • Metastatic prostate cancer 
  • Pancreatic cancer 
  • 10 or more colon polyps 
  • Diagnosis of a potentially hereditary cardiovascular condition such as cardiomyopathy2, arrhythmia3, aortopathy4, familial hypercholesterolemia, pulmonary arterial hypertension, or hereditary hemorrhagic telangiectasia
  • Early-onset cardiovascular disease:
    • ICD/Pacemaker (younger than age 50)
    • Heart failure or heart transplant (younger than age 60)
    • Early "heart attack", coronary artery disease, or stroke (males younger than age 55; females younger than age 65)
    • Aortic aneurysm/dissection (younger than age 50)
  • Untreated LDL ≥190
  • Unexplained cardiac arrest(s) or sudden death, or sudden infant death syndrome (SIDS)
  • Unexplained syncope or syncope with exercise or emotional distress
*Close blood relatives include sibling, half-sibling, parent, child, aunt/uncle, niece/nephew, grandparent, or grandchild
 
Methodology:
Next-generation sequencing (NGS)
 
Test List In Profile:
ACTA2 ACTC1 ACTN2 ACVRL1 APC APOB ATM ATP7B AXIN2 BAG3 BAP1 BARD1 BMPR1A BMPR2 BRCA1 BRCA2 BRIP1 CACNA1C CACNA1S CACNB2 CALM1 CALM2 CALM3 CASQ2 CAV1 CAV3 CDC73 CDH1 CDK4 CDKN2A CHEK2 COL3A1 CRYAB CSRP3 DES DICER1 DMD DSC2 DSG2 DSP EMD ENG EPCAM F2 F5 F9 FBN1 FH FHL1 FLCN FLNC GDF2 GLA GPD1L GREM1 HAMP HCN4 HFE HJV HOXB13 JUP KCNE1 KCNE2 KCNH2 KCNJ2 KCNQ1 KIT LAMP2 LDLR LDLRAP1 LMNA MAX MEN1 MET MITF MLH1 MSH2 MSH3 MSH6 MUTYH MYBPC3 MYH11 MYH7 MYL2 MYL3 MYLK NBN NF1 NF2 NKX25 NTHL1 OTC PALB2 PCSK9 PDGFRA PKP2 PLN PMS2 POLD1 POLE PRKAG2 PRKAR1A PRKG1 PROC PROS1 PTCH1 PTEN RAD51C RAD51D RB1 RBM20 RET RYR1 RYR2 SCN5A SDHA SDHAF2 SDHB SDHC SDHD SERPINA1 SERPINC1 SGCD SLC40A1 SMAD3 SMAD4 SMARCA4 SMARCB1 STK11 TCAP TFR2 TGFB2 TGFB3 TGFBR1 TGFBR2 TMEM127 TMEM43 TNNC1 TNNI3 TNNT2 TP53 TPM1 TSC1 TSC2 VCL VHL WT1
 
 
 
Test Code:
090-71-5524

Order Name:
INVITAE Genetic health screen (Proactive test) **

 
Patient Preparation:
Genetics Counseling
​ไม่ทำการตรวจ Proactive ในผู้ที่อายุต่ำกว่า 18 ปี 
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes

Document Require:
Completed Invitae Proactive Screen - Requesition & Consent Form
 
Specimen Testing Type:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes
 
Sub Mission Container:
Whole blood EDTA, minimum volume 6 mL
 
Rejection Criteria:
  • Hemolyzed or clotted blood
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) bone marrow transplant
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) stem cell transplant
  • Blood (or saliva) from patients who had a blood transfusion less than two weeks prior to specimen collection
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood EDTA Refrigerated, 2oC to 8oC 14 days
Saliva (2mL) in special collection kit * Ambient 30 days
* Optional, Nurse can request the special collection kit from Lab 4th Floor, Tel. 14160-2​
** Sending to USA
 
 
 
Test Code:
090-71-5524

Order Name:
INVITAE Genetic health screen (Proactive test) **

 
Method detail:
Next-generation sequencing (NGS)
 
Schedule:
N/A **Sent out to Precision Health (INVITAE, USA)
 
Turnaround Time:
20-25 days
 
Performing Location:
Precision Health (INVITAE, USA)
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5524

Order Name:
INVITAE Genetic health screen (Proactive test) **

 
 
Clinical Information:

The Invitae Genetic Health Screen analyzes more than 145 genes related to inherited cancers, cardiovascular conditions, and additional conditions that, if detected early, may have effective medical interventions and preventive measures. The Invitae Genetic Health Screen is our most comprehensive proactive health test, including all the genes analyzed in the Invitae Cancer Screen and Invitae Cardio Screen, as well as several more associated with medically actionable conditions.

 
Reference Value:
An interpretive report will be provided.
 
Interpretation:
Report integrate relevant guidelines to help develop a personalized screening and prevention plan for patients.
 
Clinical Reference:
www.invitae.com (Retrieved: 29 Jun 2020)