The Glycomark test provides quantitative measurement of 1,5-anhydroglucitol (1,5-AG) in serum . The test is indicated for the intermediate term monitoring of glycemic control in people with diabetes.
Tight glycemic control is essential for preventing the complications of diabetes. The clinical standard for evaluating glycemic control is the measurement of hemoglobin A1c (HbA1c); elevated levels (>7.0%) indicate significant hyperglycemia. However, even in patients with well-controlled HbA1c levels, postprandial glucose levels may be significantly elevated and lowering these will further improve control.
1,5-Anhydroglucitol (1,5-AG) is a glucose-like monosaccharide contained in food. Intake is normally balanced with urinary excretion; however, during periods of hyperglycemia, glucose blocks reabsorption of 1,5-AG in the renal tubules. Thus, low blood levels of 1,5-AG are associated with hyperglycemia. 1,5-AG levels change more rapidly than HbA1c levels and reflect glycemia over the previous 1-2 week period.