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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-30-1410-01
Order Name (ชื่อการทดสอบ):
Gentamicin Level
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 90 min
 
Useful For (ประโยชน์การทดสอบ):
The results obtained are used in the diagnosis and treatment of gentamicin overdose and in monitoring levels of gentamicin to help ensure appropriate therapy.
 
Methodology (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1410-01
Order Name (ชื่อการทดสอบ):
Gentamicin Level
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
Follow the instruction of physician and pharmarcist.
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: 4+ reject
Lipemia: 4+ reject
Icterus: 4+ reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, < -10oC 14 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1410-01
Order Name (ชื่อการทดสอบ):
Gentamicin Level
 
Method detail (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 90 min
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1410-01
Order Name (ชื่อการทดสอบ):
Gentamicin Level
 
 
Clinical Information (ข้อมูลทางคลินิก):
Gentamicin is used in the treatment of serious infections involving aminoglycoside-sensitive organisms. Monitoring gentamicin concentration in serum or plasma, along with careful clinical assessment, is the most effective means of ensuring adequate therapy. Gentamicin concentration correlates better with antibacterial activity than dosage. A standard dose of gentamicin does not always yield a predictable concentration because the drug’s concentration also depends on the patient’s volume of distribution and on the drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal retention, and physiological changes during therapy. Gentamicin has a narrow range of safe and effective concentration. Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity. Patients with impaired renal function should be monitored closely while on gentamicin therapy because nephrotoxicity caused by gentamicin may be difficult to distinguish from symptoms of underlying renal disease.
 
Reference Value (ค่าอ้างอิง):
Peak level: 3 – 10 µg/mL
Trough level: < 2 µg/mL

Note: The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
 
Interpretation (การแปลผล):
Periodic measurements of both peak and trough concentrations of gentamicin are recommended to ensure adequate drug levels and prevent toxic side effects. The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
 
Clinical Reference (เอกสารอ้างอิง):
  1. Manufacturer’s reagent package insert, Architect® Gentamicin, Microgenics Corporation 46500 Kato Road Fremont, CA 94538 USA .
  2. Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com (Retrieved: July 2018)
  3. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)