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Test Code:
098-10-0034-01

Order Name:
Crosslinks (Pyridinoline, Deoxypyridinoline) Urine

 
Useful For:
Monitoring test for patients to assess the bone degradation
 
Methodology:
High Performance Liquid Chromatography (HPLC)
 
Test List In Profile:
Pyridinoline (PYD)
Deoxypyridinoline (DPD)
 
AliasesName:
PYD, Urine
Pyridinoline, Urine
DPD, Urine
Deoxypyridinoline, Urine
Crosslinks, Urine
 
 
 
Test Code:
098-10-0034-01

Order Name:
Crosslinks (Pyridinoline, Deoxypyridinoline) Urine

 
Collection Specimen Or Container:
Second morning urine (between 10.00 am and noon)
 
Specimen Testing Type:
Second morning urine minimum volume 3 mL
 
Sub Mission Container:
15 mL Screw cap tube
 
Rejection Criteria:
None
 
Specimen Stabillity:
 
Specimen Type Temperature Time
Urine (between 10.00 am and noon) Refrigerated, 2oC to 8oC 7 days
Frozen, -18oC longer storage​
 
 
 
Test Code:
098-10-0034-01

Order Name:
Crosslinks (Pyridinoline, Deoxypyridinoline) Urine

 
Method detail:
High Performance Liquid Chromatography (HPLC)
 
Schedule:
Every Thursday
 
Turnaround Time:
Received to Reported within 7 Days.
 
Performing Location:
Special Lab, Laboratory Department 14141
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
098-10-0034-01

Order Name:
Crosslinks (Pyridinoline, Deoxypyridinoline) Urine

 
 
Clinical Information:
Pyridinium crosslinks (Pyridinoline and Deoxypyridinoline) guaruntee the crosslinkage between the collagen fibres in bone and cartilage. Bone degradation process release these compound and are excreted in the urine
 
Reference Value:
Sex Test Reference Value Unit
Male Pyridinoline (PYD) 23 - 65 pmol/umol creatinine
Deoxypyridinoline (DPD) 6 - 26 pmol/umol creatinine
Female Pyridinoline (PYD) 25 - 83 pmol/umol creatinine
Deoxypyridinoline (DPD) 6 - 23 pmol/umol creatinine
 
Interpretation:
Diagnosis of collagen crosslink is reliable test for evaluation of bone collagen degradation desease, for example the diagnosis of osteoperosis. High level of collagen crosslink was found in patient with osteoperosis.
 
Clinical Reference:
Instruction manual for HPLC analysis of Crosslinks in Urine