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Test Code:
090-20-2191

Order Name:
Alpha 2 Macroglobulin

 
Useful For:
Determination of alpha2-macroglobulin in samples of human origin.

Evaluation of patients with nephrotic syndrome and pancreatitis.
 
Methodology:
Immunoturbidimetry 
 
AliasesName:
AMG (Alpha-2-Macroglobulin)
Macroglobulin, Alpha-2
 
 
 
Test Code:
090-20-2191

Order Name:
Alpha 2 Macroglobulin

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis:4+ reject
 
Specimen Stabillity:
Sepcimen Type Temperature Time
Serum (in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 3 months
 
 
 
Test Code:
090-20-2191

Order Name:
Alpha 2 Macroglobulin

 
Method detail:
Immunoturbidimetry 
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 2 hours (120 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-20-2191

Order Name:
Alpha 2 Macroglobulin

 
 
Clinical Information:
The alpha2-macroglobulin is a very large size protease inhibitor (725 kDa), primarily synthesized by cells of the hepatic parenchyma. It is involved in the inhibition of enzymes involved in the kinin-kallikrein, complement, coagulation and even fibrinolytic systems. In addition to these inhibitor roles, the alpha2-macroglobulin is used as a carrier for many small peptides (such as cytokines or growth factors), and also with divalent cations (particularly zinc).

The serum concentration of alpha2-macroglobulin varies with the age and gender of the individual.
An increase in serum alpha2-macroglobulin can occur following the nephrotic syndrome. High levels are also associated with estrogen stimulation, as in pregnancy or with oral contraceptive use.
A decrease in the alpha2-macroglobulin concentration can occur due to the inflammatory phase in the case of pancreatitis, and can even indicate the presence of prostate carcinoma. The alpha2-macroglobulin level can also be lower in some individuals due to genetic variation.
 
Reference Value:
Age ≤ 18 Years: 1.78 - 4.95 g/L
Age > 18 Years: 1.00 - 2.80 g/L
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Alpha2–macroglobulin for Architect®  C8000/C16000, DiAgam Belgium, Rue du Parc Industriel 40, 7822 Ghislenghien, Belgium, v07, 21/10/2019.
  2. (*) Reference intervals (normal values): www.mayocliniclabs.com (Retrieved: Feb 2021)